PMID: 3766123Jan 1, 1986Paper

Fetal origin of the medulloblastoma: evidence from growth analysis of two cases

Acta Neuropathologica
K HirakawaJ Handa

Abstract

Growth analysis of medulloblastomas was performed in two children. They initially manifested symptoms at the age of 3 years and 9 months and at the age of 2 months respectively. Computerized tomography (CT) scans were obtained at different points in each case. The growth curves were drawn on a semilogarithmic graph by calculating the tumor volume on CT on the assumptions that the tumor started from a single tumor cell and that the growth rate was constant. By extrapolating the curves back, tumor inception was estimated to have occurred respectively at the 14-23rd week and at the 16-17th week of gestation. Additional cell kinetic data were obtained from DNA analysis of surgical pathology specimens. Calculated cell-cycle times were 22-32 h for both cases. The S phases comprised 26.3% and 27% and the G0G1 phases 66.8% and 62% of the cell cycle, respectively, for case 1 and 2. Assuming a labelling index of 14%, the cell loss factors were estimated to be 97% and 74% (case 1 and case 2 respectively). The seventeenth week of gestation in humans corresponds to the timing of events occurring postnatally at days 3-18 in the developing cerebella of rodents, i.e., at the time of maximal activity in the migration and differentiation of the ...Continue Reading

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Jan 1, 1987·Cancer Metastasis Reviews·S R VandenbergL J Rubinstein
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