PMID: 9539781May 16, 1998Paper

Fetal origins of the TEL-AML1 fusion gene in identical twins with leukemia

Proceedings of the National Academy of Sciences of the United States of America
A M FordM Greaves

Abstract

The TEL (ETV6)-AML1 (CBFA2) gene fusion is the most common reciprocal chromosomal rearrangement in childhood cancer occurring in approximately 25% of the most predominant subtype of leukemia- common acute lymphoblastic leukemia. The TEL-AML1 genomic sequence has been characterized in a pair of monozygotic twins diagnosed at ages 3 years, 6 months and 4 years, 10 months with common acute lymphoblastic leukemia. The twin leukemic DNA shared the same unique (or clonotypic) but nonconstitutive TEL-AML1 fusion sequence. The most plausible explanation for this finding is a single cell origin of the TEL-AML fusion in one fetus in utero, probably as a leukemia-initiating mutation, followed by intraplacental metastasis of clonal progeny to the other twin. Clonal identity is further supported by the finding that the leukemic cells in the two twins shared an identical rearranged IGH allele. These data have implications for the etiology and natural history of childhood leukemia.

References

Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
May 1, 1990·Journal of Clinical Pathology·K P McCarthyL M Wiedemann
Apr 3, 1971·Lancet·S D LawlerM M Till
Nov 10, 1994·Nature·T H Rabbitts
Jan 1, 1996·Current Topics in Microbiology and Immunology·T R GolubD G Gilliland
May 1, 1996·Genome Research·M BaensP Marynen
Feb 1, 1997·Lancet·M F Greaves
Feb 1, 1997·British Journal of Haematology·G CiminoG Saglio
Nov 1, 1996·Leukemia & Lymphoma·O A BernardR Berger
Jan 18, 1997·Lancet·C L Sawyers
Jun 1, 1997·Molecular and Cellular Biology·S M LewisL Czyzyk
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·K B GaleM F Greaves

❮ Previous
Next ❯

Citations

Jan 21, 2000·Hematological Oncology·S K MaL C Chan
Nov 7, 2000·Genes, Chromosomes & Cancer·S TosiL Kearney
Jul 12, 2007·Cancer Immunology, Immunotherapy : CII·Malcolm TaylorUNKNOWN UKCCS Investigators
Sep 6, 2006·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Anthony M Ford, Angel Martínez-Ramírez
Apr 14, 2005·Seminars in Cancer Biology·Stefan K Bohlander
Jan 28, 2003·Lancet·Giuseppe Roberto BurgioFranco Locatelli
Nov 7, 1999·Lancet·J L WiemelsM F Greaves
Apr 12, 2001·Cancer Genetics and Cytogenetics·M RieschD R Betts
Mar 14, 2003·Cancer Treatment Reviews·Jeffrey E Rubnitz, Ching-Hon Pui
Feb 10, 2004·Cancer Treatment Reviews·Sabine L A PlasschaertEveline S J M de Bont
Jan 24, 2002·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·L Wang, S J Chen
Oct 3, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R J Arceci
Mar 11, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M Greaves
Apr 15, 2008·Trends in Endocrinology and Metabolism : TEM·S L Blethen
Sep 3, 2003·Nature Reviews. Cancer·Mel F Greaves, Joe Wiemels
Feb 10, 2006·Nature Reviews. Cancer·Mel Greaves
Nov 25, 1998·British Journal of Haematology·S P HungerM A Bitter
Sep 1, 1999·British Journal of Haematology·J F Dimartino, M L Cleary
Nov 25, 2000·British Journal of Haematology·I Q MagalhãesM F Greaves
Jul 27, 2001·British Journal of Haematology·V H van der VeldenJ J van Dongen
Jun 13, 2002·Paediatric and Perinatal Epidemiology·Li Chong ChanFreda E Alexander
May 13, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Donald T WigleDaniel Krewski
Jan 16, 2002·Current Opinion in Oncology·Louise KellyD Gary Gilliland
Jun 10, 2003·Journal of Pediatric Hematology/oncology·Jakub Tolar, Joseph P Neglia
Jul 10, 1999·Current Opinion in Hematology·S Bhatia, L L Robison
Jun 4, 2002·Current Opinion in Hematology·Mignon L Loh, Jeffrey E Rubnitz
Oct 4, 2005·The Cancer Journal·Charles G MullighanJames R Downing
Mar 23, 2011·Biochemistry. Biokhimii︠a︡·E V Chetverina, A B Chetverin
Apr 30, 2003·Archives of Disease in Childhood. Fetal and Neonatal Edition·P F RavettoG M Taylor
Aug 27, 2002·Annual Review of Genomics and Human Genetics·Louise M Kelly, D Gary Gilliland
Mar 17, 2009·The Journal of Clinical Investigation·Anthony M FordMel Greaves
Sep 29, 2007·Blood·Minenori Eguchi-IshimaeMel Greaves
Apr 13, 2011·Blood·Frederik W van DelftMel Greaves

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.