Fetal outcomes and associated factors of adverse outcomes of pregnancy in southern Chinese women with systemic lupus erythematosus

PloS One
Zhongping ZhanXiuyan Yang

Abstract

This study aims to investigate the fetal outcomes and associated factors of adverse pregnancy outcomes (APOs) in pregnant women with systemic lupus erythematosus (SLE). Clinical data from 251 SLE patients with 263 pregnancies from 2001 to 2015 were analyzed retrospectively. APOs occurred in 70.0% of pregnancies, in which pregnancy loss occurred in 28.5%; preterm delivery occurred in 21.3%; intrauterine growth retardation occurred in 12.2%; and fetal distress occurred in 8.0%. Over time, the rate of APOs decreased from 82.8% during 2001~2005 to 59.6% during 2011~2015. In multivariate analysis, predictors of APOs included positive antiphospholipid antibodies (OR 8.4, 95% CI 1.7~40.8, P = 0.008), lower complement (OR 3.6, 95% CI 1.3~9.9, P = 0.01), hypoalbuminemia (OR 3.2, 95% CI 1.2~8.3, P = 0.02), and hypertension (OR 14.6, 95% CI 1.5~141.6, P = 0.02). The use of antimalarial medications was associated with lower risk for APOs (OR 0.3, 95% CI 0.1~0.7, P = 0.01). In total, 109 patients underwent fetal umbilical artery Doppler in the third trimester. The The adjusted systole/diastole (S/D) ratio, pulsatility index (PI) and resistance index (RI) of SLE patients with APOs were higher than that of patients without APOs (2.9±0.9 vs. 2...Continue Reading

References

Nov 24, 1999·Lupus·J P BuyonM Khamashta
Sep 15, 2000·Rheumatology·P E GeorgiouA A Drosos
Oct 20, 2001·American Journal of Reproductive Immunology : AJRI·F CarmonaJ Balasch
Sep 27, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Gabriella MoroniClaudio Ponticelli
Feb 5, 2005·Arthritis and Rheumatism·Megan E B ClowseMichelle Petri
Nov 1, 2006·Arthritis and Rheumatism·Megan E B ClowseMichelle Petri
May 15, 2007·Rheumatic Diseases Clinics of North America·Megan E B Clowse
May 17, 2007·Annals of the Rheumatic Diseases·G BertsiasUNKNOWN Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics
Aug 7, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Andrew SmythVesna D Garovic
Dec 15, 2010·Lupus·N RupertoUNKNOWN Lupus Foundation of America, Inc. International Flare Consensus Initiative
Jan 27, 2012·Clinical Rheumatology·Miguel A SaavedraLuis J Jara
Jan 31, 2013·Annals of the Rheumatic Diseases·Megan E B ClowseDavid S Pisetsky
Jun 29, 2013·Archives of Gynecology and Obstetrics·Riza MadazliHandan Yilmaz
Nov 19, 2013·Best Practice & Research. Clinical Rheumatology·Aisha Lateef, Michelle Petri
Jun 23, 2015·Annals of Internal Medicine·Jill P BuyonJane E Salmon
Aug 8, 2015·Autoimmune Diseases·Guilherme Ramires de JesusRoger Abramino Levy
Nov 4, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Giorgina Barbara PiccoliTullia Todros

❮ Previous
Next ❯

Citations

Oct 22, 2019·British Journal of Clinical Pharmacology·Claire de MoreuilElisabeth Pasquier
Sep 21, 2019·PloS One·Syahrul Sazliyana ShaharirRahana Abdul Rahman
Apr 1, 2020·International Journal of Rheumatic Diseases·Miguel Ángel SaavedraLuis Javier Jara
Dec 17, 2020·Lupus·Karel VenneEvelyne Vinet

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.