Fetal oxygen saturation and fractional extraction at birth and the relationship to measures of acidosis

American Journal of Obstetrics and Gynecology
B S RichardsonRenato Natale

Abstract

We sought to determine umbilical cord oxygen saturation and fractional oxygen extraction values as measured at birth for a large tertiary hospital population and their predictive value for measures of acidosis. The computerized perinatal database of St. Joseph's Health Centre, London, Ontario, was used to obtain the umbilical cord gases, pH, mode of delivery, gestational age at delivery, and nuchal cord status for all live-born infants >500 gm between January 1991 and December 1995 (n = 22,134). Oxygen saturation values were calculated from the umbilical cord PO2 and pH data with a previously derived empirical equation, the accuracy of which was rechecked with 100 consecutive cord blood samples where oxygen saturation values were both calculated and measured with a hemoximeter (r = 0.99, p = 0.001). Fractional oxygen extraction values were calculated from the umbilical cord oxygen saturation data. There were 18,250 "validated" paired umbilical vein and artery blood gas and pH results available for analysis after patient case exclusions for missing, unreliable, or "unphysiologic" data. For all validated patient cases, mean umbilical vein oxygen saturation was 63% +/- 16% (SD), mean umbilical artery oxygen saturation was 24% +/- ...Continue Reading

References

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Citations

Jul 12, 2003·High Altitude Medicine & Biology·Stacy Zamudio
Nov 13, 2004·Pediatric Surgery International·Stephanie A KapferMichael G Caty
Aug 22, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Samuel SmithEmily F Hamilton
Sep 25, 2001·American Journal of Obstetrics and Gynecology·F LackmanB Richardson
Dec 31, 2004·Obstetrics and Gynecology·Alison NodwellBryan Richardson
Aug 24, 2000·BJOG : an International Journal of Obstetrics and Gynaecology·G M ArikanP A Weiss
Oct 21, 2000·Endocrine Reviews· Challis JRGS J Lye
Dec 29, 1998·Current Opinion in Obstetrics & Gynecology·A K Luttkus, J W Dudenhausen
Mar 19, 2021·Pediatric Research·Anneloes G MunnekeTammo Delhaas

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