Fetal programming: causes and consequences as revealed by studies of dietary manipulation in rats -- a review

Placenta
Harry J McArdleLorraine Gambling

Abstract

During pregnancy, the developing fetus is dependent on its mother for all nutritional requirements. It is not surprising, therefore, that variations in maternal nutrition can be reflected in alterations in fetal health and well-being. Interestingly, the changes can persist into adulthood and may result in increased risk of diseases such as diabetes, obesity and cardiovascular disease. The first observations of these phenomena resulted in the development of hypotheses collectively brought under the heading of "fetal" or, more recently, "developmental" programming. In this review, we will examine some of the animal models used to understand the mechanisms involved and attempt to determine whether there are common, "gatekeeper", pathways or genes, altered by the different nutritional stresses. We will concentrate primarily on nutrition related to post-natal development of hypertension and will restrict the review to studies in rodents, since that is where most of the mechanistic studies are being undertaken. Our conclusions are that, while there may well be some common gatekeeper pathways, there is also some diversity of mechanism which may contribute to the generation of the same or similar phenotypes.

Citations

Oct 25, 2011·Obstetrical & Gynecological Survey·Dahlia Raymond, Erika Peterson
Mar 23, 2012·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Fernanda R C L AlmeidaHélio Chiarini-Garcia
Jan 1, 2006·Tobacco Induced Diseases·Hugo T Bergen
Apr 5, 2013·PloS One·Corina AndersAdrian S Woolf
Apr 9, 2014·The British Journal of Nutrition·Margaret P RaymanChristopher W G Redman
May 19, 2012·Behavioural Brain Research·Ateret Rosenfeld, Aron Weller
Oct 27, 2012·Physiological and Biochemical Zoology : PBZ·C MarksB Bagatto
Jun 7, 2011·Seminars in Fetal & Neonatal Medicine·Constantin YanicostasPierre Rustin
May 15, 2007·Ecology Letters·Judy A Stamps
Jan 4, 2007·The Journal of Pathology·S E Greenwald
Jul 7, 2012·Paediatric and Perinatal Epidemiology·Benjamin W Chaffee, Janet C King
Aug 5, 2006·Early Human Development·Hans DemmelmairBerthold Koletzko
Dec 22, 2014·Neuroscience and Biobehavioral Reviews·Andre S MecawiJuan Arguelles
Mar 28, 2013·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·D F PinheiroM L M Vicentini-Paulino
Dec 12, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Carlos Menendez-CastroAndrea Hartner
Oct 21, 2015·The Cochrane Database of Systematic Reviews·Juan Pablo Peña-RosasTherese Dowswell
Aug 2, 2014·Journal of Developmental Origins of Health and Disease·A M Vaiserman
Dec 21, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Fatima L C SardinhaEmilio Herrera
Apr 24, 2007·The Journal of Nutrition·John L BeardByron C Jones
Aug 19, 2007·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Karolina Kublickiene, Stefan Agewall
Feb 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Trevor Tapiwa NyakudyaKennedy Honey Erlwanger
Jan 27, 2019·International Journal of Molecular Sciences·Marilia Martins CavarianiRaquel Fantin Domeniconi
Jun 17, 2011·The American Journal of Clinical Nutrition·Sophie HawkesworthSophie E Moore

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