PMID: 11906910Mar 22, 2002Paper

Fetal programming: prenatal androgen disrupts positive feedback actions of estradiol but does not affect timing of puberty in female sheep

Biology of Reproduction
Tejinder Pal SharmaVasantha Padmanabhan

Abstract

We studied the impact of prenatal androgen exposure on the timing of onset of puberty, maintenance of cyclicity in the first breeding season, and the LH surge mechanism in female sheep. Pregnant sheep were injected with testosterone propionate (100 mg i.m.) twice each week from Day 30 to Day 90 (D30-90) or from Day 60 to Day 90 (D60-90) of gestation (term = 147 days). Concentrations of plasma progesterone and gonadotropins were measured in blood samples collected twice each week from control (n = 10), D60-90 (n = 13), and D30-90 (n = 3) animals. Rate of weight gain and initiation of estrous behavior were also monitored. After the first breeding season, when the animals entered anestrus, competency of the gonadotropin surge system to respond to estradiol positive feedback was tested in the absence or presence of progesterone priming for 12 days. Prenatally androgenized females had similar body weight gain and achieved puberty (start of first progestogenic cycle) at the same time as controls. Duration of the breeding season and the number of cycles that occurred during the first breeding season were similar between control and prenatally androgenized sheep. In contrast, prenatal exposure to androgens compromised the positive feed...Continue Reading

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Citations

Jul 31, 2007·Reviews in Endocrine & Metabolic Disorders·Daniel A DumesicVasantha Padmanabhan
Jun 29, 2011·Seminars in Reproductive Medicine·Vasantha Padmanabhan, Almudena Veiga-Lopez
Oct 22, 2010·Human Reproduction Update·Deborah M SlobodaRoger Hart
Apr 28, 2004·ILAR Journal·David H AbbottDaniel A Dumesic
Mar 28, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Luis Miguel Garcia-SeguraLydia L DonCarlos
Sep 30, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Jane Robinson
May 31, 2014·Physiology & Behavior·Joanna H SliwowskaMichael N Lehman
Apr 22, 2014·Frontiers in Neuroendocrinology·Alison V Roland, Suzanne M Moenter
May 25, 2013·Steroids·Vasantha Padmanabhan, Almudena Veiga-Lopez
Oct 23, 2012·Molecular and Cellular Endocrinology·Vasantha Padmanabhan, Almudena Veiga-Lopez
Jul 29, 2011·Fertility and Sterility·César Díaz-GarcíaCarlos Simón
Feb 18, 2014·Experimental Physiology·Fahimeh Ramezani TehraniFereidoun Azizi
May 26, 2006·Molecular and Cellular Endocrinology·Douglas L FosterVasantha Padmanabhan
Jan 18, 2006·Molecular and Cellular Endocrinology·Vasantha PadmanabhanDouglas Foster
Sep 21, 2013·Molecular and Cellular Endocrinology·Elena ZambranoPeter W Nathanielsz
Mar 21, 2015·The Journal of Endocrinology·Fabio V ComimStephen Franks
May 5, 2016·Theriogenology·Neil P EvansJane E Robinson
May 26, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Muraly PuttabyatappaVasantha Padmanabhan
Nov 9, 2016·Molecular Neurobiology·Tuong-Vi NguyenSherif Karama
May 30, 2017·Frontiers in Neuroendocrinology·Aleisha M Moore, Rebecca E Campbell
Apr 22, 2003·American Journal of Human Biology : the Official Journal of the Human Biology Council·Deborah K Barnett, David H Abbott

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