Fetal programming: testosterone exposure of the female sheep during midgestation disrupts the dynamics of its adult gonadotropin secretion during the periovulatory period

Biology of Reproduction
Mozhgan SavabieasfahaniVasantha Padmanabhan

Abstract

Prenatal exposure of the female sheep to excess testosterone (T) leads to hypergonadotropism, multifollicular ovaries, and progressive loss of reproductive cycles. We have determined that prenatal T treatment delays the latency of the estradiol (E2)-induced LH surge. To extend this finding into a natural physiological context, the present study was conducted to determine if the malprogrammed surge mechanism alters the reproductive cycle. Specifically, we wished to determine if prenatal T treatment 1) delays the onset of the preovulatory gonadotropin surge during the natural follicular phase rise in E2, 2) alters pulsatile LH secretion and the dynamics of the secondary FSH surge, and 3) compromises the ensuing luteal function. Females prenatally T-treated from Day 60 to Day 90 of gestation (147 days is term) and control females were studied when they were approximately 2.5 yr of age. Reproductive cycles of control and prenatally T-treated females were synchronized with PGF2alpha, and peripheral blood samples were collected every 2 h for 120 h to characterize cyclic changes in E2, LH, and FSH and then daily for 14 days to monitor changes in luteal progesterone. To assess LH pulse patterns, blood samples were also collected freque...Continue Reading

References

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Citations

Jan 24, 2009·Biology of Reproduction·Lori M GortonRuth I Wood
Apr 22, 2014·Frontiers in Neuroendocrinology·Alison V Roland, Suzanne M Moenter
Oct 23, 2012·Molecular and Cellular Endocrinology·Vasantha Padmanabhan, Almudena Veiga-Lopez
Jan 18, 2006·Molecular and Cellular Endocrinology·Vasantha PadmanabhanDouglas Foster
Sep 21, 2013·Molecular and Cellular Endocrinology·Elena ZambranoPeter W Nathanielsz
Dec 18, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·K A Walters
Oct 11, 2005·American Journal of Physiology. Endocrinology and Metabolism·Sergio E RecabarrenTeresa Sir-Petermann
Jul 31, 2014·Journal of Animal Science·V Padmanabhan, A Veiga-Lopez
Apr 21, 2020·Endocrine Reviews·Elisabet Stener-VictorinDavid H Abbott
Jul 4, 2021·Journal of Neuroendocrinology·Aisha SatiRebecca E Campbell

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