Fetal protein malnutrition impairs acquisition of a DRL task in adult rats

Physiology & Behavior
J TonkissR R Timm

Abstract

Developing rats were either malnourished or adequately nourished during the prenatal period by feeding their dams diets of 6% (low) or 25% (adequate) casein content 5 weeks prior to mating and throughout pregnancy. All pups received adequate nutrition from the day of birth onwards. Beginning at 160 days of age male rats were tested in a DRL-18 sec operant task. It was found that prenatal malnutrition impaired performance during acquisition, though asymptomatic levels were not significantly different. Subsequent limited hold DRL-18 sec schedules in which late as well as early responses went unrewarded indicated that the timing ability of the prenatally malnourished rats was excellent and similar to that of the controls. These late effects of fetal protein malnutrition are discussed in terms of the difficulty in adapting to the change from CRF to DRL-18 sec (possibilities include a reduced ability to develop a timing strategy or increased sensitivity to the change in reinforcement contingencies), while retaining the ability to time responses accurately once the task was acquired.

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Citations

Jul 1, 1992·Journal of the Neurological Sciences·J S Chopra, A Sharma
Nov 1, 1990·Physiology & Behavior·J TonkissJ R Galler
Feb 1, 1994·Physiology & Behavior·J TonkissJ R Galler
Jun 1, 1994·Physiology & Behavior·J R GallerC S Maldonado-Irizarry
Apr 1, 1997·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·J C ChenL Volicer
Mar 15, 1993·Annals of the New York Academy of Sciences·J TonkissR J Austin-LaFrance
Aug 11, 2007·Learning & Behavior·Jason LandonBernhard H Breier
Nov 3, 2010·Nutritional Neuroscience·C T ValadaresS S Almeida
Oct 26, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·L A Reyes-CastroE Zambrano
Jan 1, 1993·Neuroscience and Biobehavioral Reviews·P J MorganeJ R Galler
Nov 17, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·L A Reyes-CastroE Zambrano
Sep 2, 2008·Physiology & Behavior·Heather R Mattila, Brian H Smith
Nov 18, 2018·Nutrition Reviews·Rafael BarraAlejandro Hernández
Apr 11, 2012·Neuroscience and Biobehavioral Reviews·Meryem Alamy, Wail A Bengelloun

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