PMID: 7034870Dec 1, 1981Paper

Fetal raphe and hippocampal transplants into adult and aged C57BL/6N mice: a preliminary immunocytochemical study

Brain Research Bulletin
E AzmitiaJ M Lauder

Abstract

Fetal mouse raphe and hippocampal tissue (from embryos with crown-rump length (CRL) 13-16 mm) was transplanted into adult and aged isogenetic mice to study the growth of serotonergic fibers between host and donor tissue. A specific antibody against serotonin (5-HT) was used to immunocytochemically visualize 5-HT containing cell bodies and fibers. Unilateral fetal transplants into the hippocampi of adult (4-6 mo.) or aged (24 mo.) mice matured and sent out processes which very densely innervated the transplant tissue itself and extended into the host hippocampus. The termination of these fibers was consistent with the known 5-HT-hippocampal lamination pattern in normal animals. Qualitative comparisons suggested that the density of outgrowth into adult hippocampus was greater than into aged hippocampus. Conversely, adult 5-HT neurons send sprouts into fetal hippocampal tissue transplanted into the lateral ventricle. Therefore, immunocytochemical procedures can be used to monitor outgrowth from the fetal tissue to the host and ingrowth from the adult host to the fetal tissue. Furthermore, the apparent normal 5-HT lamination pattern produced by fetal raphe axons in adult hippocampus is consistent with reports that neuronal transpla...Continue Reading

References

Sep 27, 1978·Anatomy and Embryology·P Levitt, R Y Moore
Nov 17, 1978·Science·S W ScheffC W Cotman
Jul 17, 1981·Neuroscience Letters·M FrankfurtE C Azmitia
Jan 1, 1981·Peptides·C G CharltonD M Jacobowitz

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Citations

Apr 1, 1991·Journal of Neurology·S B Dunnett
Nov 18, 1985·Brain Research·A MatsumotoM Osanai
Apr 9, 1986·Brain Research·F F Marciano, D M Gash
Sep 1, 1993·Physiology & Behavior·F García-HernándezR Drucker-Colín
Aug 1, 1991·Trends in Neurosciences·S Dunnett
Apr 1, 1995·Brain Research. Molecular Brain Research·S UedaE C Azmitia
Jan 1, 1985·Neurobiology of Aging·A S KaplanP D Coleman
Jan 1, 1989·Progress in Neuro-psychopharmacology & Biological Psychiatry·S D Iversen, S B Dunnett
Oct 24, 1985·Neuroscience Letters·S AuerbachE Azmitia
Jan 1, 1987·Neuroscience·E C Azmitia, P M Whitaker-Azmitia
Nov 1, 1995·Neuroscience·E C PappT F Freund
Jun 1, 1990·Brain Research Bulletin·H OgawaK Ishikawa
Jan 1, 1996·Brain Research Bulletin·S UedaM Kawata
Jan 1, 1991·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·E C AzmitiaF C Zhou
Nov 1, 1991·Psychological Medicine·S B Dunnett
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M Nieto-SampedroC W Cotman
Jan 1, 1990·The European Journal of Neuroscience·S. B. Dunnett
Jan 1, 1990·Annals of the New York Academy of Sciences·E C AzmitiaF C Zhou

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