Fetal sheep endocrine responses to sustained hypoxemic stress after chronic fetal placental embolization

The American Journal of Physiology
R GagnonB S Richardson

Abstract

The purpose of this study was to determine the endocrine and circulatory responses of the ovine fetus, near term, to sustained hypoxemic stress superimposed on chronic hypoxemia. Fetal sheep were chronically embolized (n = 7) for 10 days between 0.84 and 0.91 of gestation via the descending aorta until arterial oxygen content was decreased by approximately 30%. Control animals (n = 8) received saline only. On experimental day 10, both groups were embolized over a 6-h period until fetal arterial pH decreased to approximately 7.00. Regional distribution of lower body blood flows was measured on day 10, before and at the end of acute embolization. On day 10, the chronically embolized group had lower arterial oxygen content (P < 0.05), Po2 (P < 0.01), and placental blood flow (P < 0.05) than controls and higher prostaglandin E2 (PGE2) and norepinephrine plasma concentrations (both P < 0.05). In response to a superimposed sustained hypoxemic stress, there was a twofold greater increase in PGE2 in the chronically embolized group than in the control group (P < 0.05). However, the increase in fetal plasma cortisol in response to superimposed hypoxemic stress was similar in both groups, despite significantly lower adrenocorticotropic ho...Continue Reading

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Citations

Mar 16, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Keiichi AdachiCharles A Ducsay
Jul 16, 2015·American Journal of Physiology. Endocrinology and Metabolism·Elizabeth A NewbyCharles A Ducsay
May 3, 2018·Physiological Reviews·Charles A DucsayLubo Zhang
May 9, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J M Bassett, C Hanson
Jul 27, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Bert WibbensAlistair J Gunn
Oct 27, 2015·The Journal of Physiology·Dino A Giussani

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