Fetal striatal grafting slows motor and cognitive decline of Huntington's disease

Journal of Neurology, Neurosurgery, and Psychiatry
Marco PaganiniPasquale Gallina

Abstract

To assess the clinical effect of caudate-putaminal transplantation of fetal striatal tissue in Huntington's disease (HD). We carried out a follow-up study on 10 HD transplanted patients and 16 HD not-transplanted patients. All patients were evaluated with the Unified HD Rating Scale (UHDRS) whose change in motor, cognitive, behavioural and functional capacity total scores were considered as outcome measures. Grafted patients also received morphological and molecular neuroimaging. Patients were followed-up from disease onset for a total of 309.3 person-years (minimum 5.3, median 11.2 years, maximum 21.6 years). UHDRS scores have been available since 2004 (median time of 5.7 years since onset, minimum zero, maximum 17.2 years). Median post-transplantation follow-up was 4.3 years, minimum 2.8, maximum 5.1 years. Adjusted post-transplantation motor score deterioration rate was reduced compared to the pretransplantation period, and to that of not-transplanted patients by 0.9 unit/years (95% CI 0.2 to 1.6). Cognitive score deterioration was reduced of 2.7 unit/years (95% CI 0.1 to 5.3). For grafted patients the 2-year post-transplantation [(18)F]fluorodeoxyglucose positron emission tomography (PET) showed striatal/cortical metabolic ...Continue Reading

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Citations

Oct 15, 2014·Neurodegenerative Disease Management·Janelle Drouin-Ouellet
Feb 1, 2017·Neurochemistry International·Sophie V PreciousAnne E Rosser
Dec 9, 2016·Expert Opinion on Investigational Drugs·Thomas Müller
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Oct 17, 2018·Neural Regeneration Research·Giulia GuarnieriAnnamaria Morelli
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Nov 12, 2020·Stem Cells·Anne-Catherine Bachoud-LéviAnne Rosser

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