PMID: 11934529Apr 6, 2002Paper

Fetal testosterone insufficiency and abnormal proliferation of Leydig cells and gonocytes in rats exposed to di(n-butyl) phthalate

Reproductive Toxicology
E MylchreestPaul M D Foster

Abstract

Adult male rats previously exposed on gestation days (GD) 12-21 to di(n-butyl) phthalate (DBP) have reproductive tract malformations, particularly agenesis of the epididymis, decreased sperm production, and Leydig cell hyperplasia and adenomas. Although similar effects are produced by the potent androgen receptor (AR) antagonist flutamide and are indicative of disruption of male sexual differentiation via an antiandrogenic mechanism, DBP is not an AR antagonist. The purpose of the study was to determine whether DBP causes pathologic changes and alterations in androgen status in the testis during the prenatal period of male reproductive tract differentiation. Pregnant CD rats were given corn oil, DBP (500 mg/kg/day), or flutamide (100 mg/kg/day) p.o. on GD 12-21. At GD 16-21, DBP caused hyperplasia of Leydig cells, many of which were 3beta-hydroxysteroid dehydrogenase- and/or AR-positive. Focal areas of hyperplasia had increased numbers of Leydig cells positive for proliferating cell nuclear antigen (PCNA). At GD 21, testis atrophy was apparent, seminiferous cords in DBP-exposed fetuses were enlarged and contained multinucleated gonocytes that, unlike controls, were PCNA-positive. DBP, but not flutamide, markedly decreased testi...Continue Reading

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Citations

Jun 4, 2005·Analytical and Bioanalytical Chemistry·Gerda K MortensenNiels E Skakkebaek
Apr 12, 2008·International Archives of Occupational and Environmental Health·Kristina Jakobsson, Zoli Mikoczy
Feb 14, 2013·Fish Physiology and Biochemistry·Thea M EdwardsLouis J Guillette
Jan 29, 2013·Environmental Science and Pollution Research International·Edith GuibertPascal Froment
Apr 17, 2002·Reproductive Toxicology·Barry S McIntyrePaul M D Foster
Aug 16, 2011·Asian Journal of Andrology·Ai-Mei BaoJia-Hao Sha
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Nov 8, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·Sheela SathyanarayanaShanna Helen Swan

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