Fetal umbilical, cerebral and pulmonary blood flow patterns in relation to lung function and asthma in childhood. The Generation R Study

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
M N KooijmanL Duijts

Abstract

Fetal growth restriction is associated with higher risks of childhood respiratory morbidity. Fetal blood flow adaptations might contribute to these associations. We examined the associations of fetal umbilical, cerebral, and pulmonary blood flow with wheezing patterns, lung function, and asthma in childhood. In a population-based prospective cohort study among 903 children, we measured fetal umbilical, cerebral, and pulmonary blood flow by pulsed-wave Doppler at a median gestational age of 30.3 (95% range 28.8-32.3) weeks. We obtained information about wheezing patterns until the age of 6 years by questionnaires. Lung function was measured by spirometry and information about current asthma was obtained by questionnaire at the age of 10 years. Results showed a non-significant relationship between a higher umbilical artery pulsatility index (PI) and umbilical artery PI/cerebral artery PI ratio, indicating fetal blood flow redistribution at the expense of the trunk, with higher risks of early wheezing (OR [95% CI]: 2.07 (0.70-6.10) and 2.74 (0.60, 12.62) per unit increase, respectively). A higher pulmonary artery time velocity integral, indicating higher pulmonary vascular resistance, was associated with a higher risk of late/pers...Continue Reading

References

Mar 1, 1992·Obstetrics and Gynecology·D GramelliniA Merialdi
Jan 19, 1995·The New England Journal of Medicine·F D MartinezW J Morgan
Jun 10, 2000·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·G Mielke, N Benda
Feb 15, 2001·American Journal of Obstetrics and Gynecology·M L CockR Harding
Apr 2, 2003·Seminars in Neonatology : SN·Sheila G Haworth, Alison A Hislop
Nov 25, 2003·Pediatric Research·Gert S MaritzRichard Harding
Apr 3, 2004·Seminars in Perinatology·Ahmet A Baschat, Kurt Hecher
Aug 2, 2005·The European Respiratory Journal·M R MillerUNKNOWN ATS/ERS Task Force
Aug 6, 2005·Early Human Development·Gert S MaritzRichard Harding
Jun 14, 2006·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·T KiserudS Rasmussen
Jul 9, 2008·Gynecologic and Obstetric Investigation·S Degani
Jun 10, 2010·Cardiovascular Ultrasound·Vincent RouleEric Saloux
Jun 7, 2011·American Journal of Respiratory and Critical Care Medicine·Steve TurnerGraham Devereux
Jan 27, 2012·Seminars in Fetal & Neonatal Medicine·Katharine PikeJane S Lucas
Feb 22, 2012·European Journal of Epidemiology·Liesbeth Duijts
Jun 30, 2012·The European Respiratory Journal·Philip H QuanjerUNKNOWN ERS Global Lung Function Initiative
Jul 4, 2013·Acta Paediatrica·T F McElrathUNKNOWN ELGAN Study Investigators
Jan 17, 2014·The Lancet. Respiratory Medicine·Janet StocksSamatha Sonnappa
Jan 13, 2015·Nutrients·Song ZhangJanna L Morrison
Jan 30, 2015·International Journal of Epidemiology·Daniela ZugnaFranca Rusconi
Jul 18, 2015·The British Journal of Dermatology·J I SilverbergE L Simpson
Nov 7, 2015·The European Respiratory Journal·Seif O ShaheenA John Henderson
Nov 10, 2015·The Journal of Allergy and Clinical Immunology·Herman T den DekkerLiesbeth Duijts
Jan 11, 2017·European Journal of Epidemiology·Marjolein N KooijmanVincent W V Jaddoe
Dec 23, 2017·American Journal of Respiratory and Critical Care Medicine·Bradley WallaceSteven H Abman

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Citations

May 31, 2019·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Philippe Eigenmann
Dec 10, 2020·Clinical and Translational Allergy·J BousquetM Jutel
Jan 20, 2021·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Philippe Eigenmann
Jul 22, 2021·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Katarina HildeGuttorm Haugen

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