Fetal undernutrition is associated with perinatal sex-dependent alterations in oxidative status

The Journal of Nutritional Biochemistry
Pilar Rodríguez-RodríguezSilvia M Arribas

Abstract

Intrauterine growth retardation predisposes to hypertension development, known as fetal programming. Females are less susceptible, which has been mainly attributed to estrogen influence. We hypothesize that perinatal differences in oxidative status might also contribute. We studied 21-day-old (prepuberal) and 6-month-old male and female offspring from rats fed ad libitum during gestation (Control) or with 50% of Control daily intake from day 10 to delivery (maternal undernutrition, MUN). We assessed in vivo blood pressure and the following plasma biomarkers of oxidative status: protein carbonyls, thiols, reduced glutathione (GSH), total antioxidant capacity, superoxide anion scavenging activity (SOSA) and catalase activities; we calculated a global score (oxy-score) from them. Estradiol and melatonin concentration was measured in young rats. Prepuberal MUN males were normotensive but already exhibited increased carbonyls and lower thiols, GSH, SOSA and melatonin; oxy-score was significantly lower compared to Control males. Prepuberal MUN females only exhibited reduced SOSA compared to Control females. Adult rats from all experimental groups showed a significant increase in carbonyls and a decrease in antioxidants compared to pr...Continue Reading

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Citations

Aug 23, 2016·Molecular Nutrition & Food Research·Silvia RodrigoCarlos Bocos
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Jun 8, 2018·Frontiers in Physiology·Pilar Rodríguez-RodríguezSilvia M Arribas
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