PMID: 8606884Nov 1, 1995Paper

Fetal urinary insulin-like growth factor I and binding protein 3 in bilateral obstructive uropathies

Prenatal Diagnosis
L BussieresC Sachs

Abstract

Fetal urinary concentrations of insulin-like growth factor I (UIGF-I) and binding protein 3 (UIGFBP-3) were determined in patients with prenatal diagnosis of bilateral obstructive uropathy. Patients were retrospectively assigned to three groups, on the basis of outcome: group 1, termination of pregnancies (n = 11) with sonographic evidence of severe oligohydramnios or renal dysplasia, confirmed at histological examination; group 2, patients (n = 10) with postnatal plasma creatinine > 50 mumol/l at the age of 1 year (1 yr-pCreat); and group 3, patients (n = 16) with 1 yr-pCreat < or = mumol/l. The results show a significant increase in UIGF-I and UIGFBP-3 in groups 1 (18,159 +/- 9083 pg/ml; 2657 +/- 669 ng/ml) and 2 (1574 +/- 847 pg/ml; 176 +/- 50 ng/ml) in comparison with group 3 (35 +/- 6 pg/ml; 21 +/- 2 ng/ml). UIGF-I and UIGFBP-3 were significantly correlated with postnatal plasma creatinine, and were both sensitive (90 per cent; 80 per cent) and specific (88 per cent; 88 per cent) for prediction of elevated 1 yr-pCreat (> 50 mumol/l). Fetal urinary IGF-I and IGFBP-3 are increased in severe fetal bilateral obstructive uropathy, possibly reflecting tubular dysfunction or/and increased synthesis consequent upon fetal kidney in...Continue Reading

References

Sep 1, 1977·The Journal of Clinical Investigation·R W FurlanettoA J D'Ercole
Jan 1, 1992·British Journal of Obstetrics and Gynaecology·U NicoliniJ Beacham
Mar 1, 1992·American Journal of Obstetrics and Gynecology·K H NicolaidesC F Moniz
May 1, 1990·American Journal of Obstetrics and Gynecology·T M CrombleholmeR A Filly
Jan 1, 1989·Progress in Growth Factor Research·R C Baxter, J L Martin
Jul 1, 1988·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·S A HaydenW H Clewell
Feb 1, 1988·Prenatal Diagnosis·A ReussM F Niermeijer
Jun 1, 1987·The Journal of Clinical Endocrinology and Metabolism·N HizukaK Shizume
Dec 1, 1987·The Journal of Clinical Endocrinology and Metabolism·T QuattrinM H MacGillivray
Jul 1, 1970·Acta paediatrica Scandinavica·R A DonckerwolckeH A Tiddens
Jul 1, 1984·Radiology·B S MahonyM R Harrison
Feb 1, 1994·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·P A TomlinsonC Chantler
Oct 1, 1993·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·M R HammermanG Ryan
Jul 1, 1993·The American Journal of Physiology·D J Benos
Jan 1, 1993·American Journal of Obstetrics and Gynecology·S LipitzC H Rodeck

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Citations

Dec 18, 2001·Prenatal Diagnosis·C A Peters
Apr 29, 1999·Current Opinion in Obstetrics & Gynecology·M P Johnson, A L Freedman
Oct 2, 2007·Best Practice & Research. Clinical Obstetrics & Gynaecology·R K Morris, Mark D Kilby
Sep 1, 2007·Seminars in Fetal & Neonatal Medicine·David LissauerMark D Kilby
Sep 5, 2001·Advances in Renal Replacement Therapy·A S Woolf, N Thiruchelvam
May 29, 1998·British Journal of Urology·C A Peters
Aug 26, 1998·Obstetrics and Gynecology Clinics of North America·D M Stamilio, M A Morgan

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