PMID: 9531145Apr 8, 1998Paper

Fetotoxicity and teratogenesis of SWL treatment in the rabbit

Journal of Endourology
A Frankenschmidt, M Heisler

Abstract

The potential effects of extracorporeal application of shockwaves on an embryo or fetus were explored in an animal model. In experimental Series A, the fetuses of 30 gravid rabbits were exposed to piezoelectrically induced and sonographically guided shockwaves on Day 25 or 20 of gestation under technical conditions corresponding to extracorporeal lithotripsy in humans. Fetotoxicity was examined by abdominal section 24 hours or 9 days later, and immediate/intermediate damage was assessed (resorptions, viability, gross injuries, and microscopic lesions of the target and neighboring fetuses). In series B, the kidneys of an additional 28 gravid rabbits (including a control group) were exposed to the same shockwave treatment on Day 11 of gestation in order to investigate indirect embryotoxic effects, including teratogenic potency. One day before the expected birth, the maternal kidneys, uteri, and adjacent organs were examined for lesions, and the 156 offspring were assessed for embryolethal, embryonoxious, or teratogenic sequelae. Shockwave targeting of the cranium, thorax, abdomen, or placenta was usually lethal to the fetuses. When the uterine wall or the space between two fetuses was targeted, the fetuses suffered from superfici...Continue Reading

References

Jan 1, 1990·Ultrasound in Medicine & Biology·C HartmanE L Carstensen
Jul 1, 1989·British Journal of Urology·G J NeerhutD A Tolley
Jan 1, 1989·Ultrasound in Medicine & Biology·F BrümmerD F Hülser
Mar 1, 1989·The Journal of Urology·D L McCulloughE G Furr
Apr 1, 1988·The Journal of Urology·M MarbergerI Steinkogler

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Citations

Feb 17, 2006·European Urology·Andreas SkolarikosJean de la Rosette
Feb 7, 2015·Scientific Reports·Maren C KiesslingChristoph Schmitz
Aug 25, 1999·Current Opinion in Urology·D A Tolley, P Downey

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