Fetuin-A and its relation to metabolic syndrome and fatty liver disease in obese children before and after weight loss

The Journal of Clinical Endocrinology and Metabolism
Thomas Reinehr, Christian L Roth

Abstract

There are very limited data available concerning the relationships between fetuin-A, weight status, nonalcoholic fatty liver disease (NAFLD), and features of the metabolic syndrome (MetS) in obese humans, and especially in children. Our objective was to study the longitudinal relationships between fetuin-A, NAFLD, and MetS in obese children. This was a 1-yr longitudinal follow-up study. This study was performed in primary care. A total of 36 obese and 14 lean children was included in the study. An outpatient 1-yr intervention program based on exercise, behavior, and nutrition therapy was performed. Changes of weight status (sd score-body mass index), waist circumference, fetuin-A, blood pressure, lipids, transaminases, insulin resistance index homeostasis model assessment (HOMA), and prevalence of NAFLD (defined by liver ultrasound) were calculated. The 12 obese children with NAFLD had significantly higher fetuin-A levels (0.35+/-0.07 g/liter) than the 24 obese children without NAFLD (0.29+/-0.06 g/liter) and the 14 normal weight children (0.29+/-0.05 g/liter). Fetuin-A levels were independent of age, pubertal stage, and gender. Fetuin-A correlated significantly to systolic (r=0.50) and diastolic blood pressure (r=0.41), insuli...Continue Reading

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