Fetuin-A in Metabolic syndrome: A systematic review and meta-analysis

PloS One
Xiongfeng PanAizhong Liu

Abstract

Fetuin-A has been associated with the progression of metabolic syndrome, but previous studies found inconsistent results on the relationship between metabolic syndrome and the concentration of fetuin-A. The aim of this study was to perform a meta-analysis to summarize previous findings on this relationship. This study was registered with the International Prospective Register of Systematic Reviews PROSPERO (CRD42019129566). Studies examining the relationship between metabolic syndrome and the concentration of circulating fetuin-A were identified using a systematic search in the electronic databases of Embase, PubMed, Web of Science, and Cochrane Library before March 2019. A random effects model was used to summarize the effect size of the association in terms of the standardized mean difference (SMD). Fourteen eligible studies compared fetuin-A concentrations between 4,551 metabolic syndrome patients and 8,805 controls. The circulating fetuin-A concentration was significantly higher in the metabolic syndrome patients than in the controls (SMD = 0.65, 95% confidence interval (CI): 0.48 to 0.83, Z = 7.18, p<0.001). Besides, circulating fetuin-A was a risk factor for metabolic syndrome (odds ratio 1.23, 95% CI: 1.08 to 1.40). Thes...Continue Reading

References

Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Mar 13, 2008·PloS One·Anita M HennigeNorbert Stefan
Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
Aug 3, 2012·The Journal of Clinical Endocrinology and Metabolism·Bernhard M KaessNicole L Glazer
Jul 16, 2013·Journal of Clinical Laboratory Analysis·Bülent HuddamSiren Sezer
Aug 21, 2013·Biochemical Pharmacology·Tae Woo JungKyung Mook Choi
Jun 19, 2014·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·D WeghuberT M Stulnig
Dec 4, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J F TrepanowskiK A Varady
Sep 8, 2015·Contemporary Clinical Trials·Rebecca DerSimonian, Nan Laird
Jul 18, 2017·Journal of the American Heart Association·Justin P ZachariahRamachandran S Vasan
Dec 20, 2018·Frontiers in Molecular Neuroscience·Xiongfeng PanAizhong Liu
Jan 31, 2019·World Journal of Diabetes·Daniella Lent-SchochetIshwarlal Jialal

❮ Previous
Next ❯

Citations

Apr 25, 2020·International Journal of Environmental Research and Public Health·Xiongfeng PanJiayou Luo
Dec 8, 2020·Molecular Metabolism·Sharon O Jensen-Cody, Matthew J Potthoff
Jun 1, 2021·Frontiers in Immunology·Xiongfeng PanAizhong Liu
Aug 28, 2021·Cells·Alejandra Romero, Juergen Eckel

❮ Previous
Next ❯

Methods Mentioned

BETA
gastric bypass

Software Mentioned

EpiData
metafor
R
Excel
Cochrane
meta

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Pharmacy and Pharmacology
Monika SinghNikhlesh Kumar
Minerva urologica e nefrologica = The Italian journal of urology and nephrology
Z AydinR Kazancioğlu
Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Satinath MukhopadhyayDeep Dutta
Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
Anna Maria DabrowskaDariusz Duma
© 2021 Meta ULC. All rights reserved