Tumour necrosis factor (TNF), a polypeptide produced by mononuclear phagocytes, has been implicated as an important mediator of inflammatory processes and of clinical manifestations in acute infectious diseases. To study further the potential role of TNF in infectious diseases, recombinant Escherichia coli (E. coli) derived human (r.HuTNF-alpha) and bovine TNF (r.BoTNF-alpha) were intravenously (i.v.) administered in dwarf goats. Rectal temperature, heart rate, rumen motility, plasma zinc and iron concentrations, and certain other blood biochemical and haematological values were studied and compared with the changes seen after E. coli endotoxin (LPS) was administered (dose: 0.1 microgram/kg i.v.). Following a single injection of 4 micrograms/kg of r.BoTNF-alpha, shivering and biphasic febrile response were observed, accompanied by tachycardia, inhibition of rumen contractions, drop in plasma zinc and iron concentrations, lymphopenia, and neutropenia followed by neutrophilia. The i.v. administration of a single injection of 4 micrograms/kg r.HuTNF-alpha induced shivering and biphasic febrile responses, accompanied by anorexia and a similar drop in plasma trace metal concentrations when compared with r.BoTNF-alpha-treated goats. ...Continue Reading
Administration of bacterial lipopolysaccharide elicits circulating tumor necrosis factor-alpha in neonatal calves.
Effects of E. coli endotoxin, some interferon-inducers, recombinant interferon- alpha 2a and Trypanosoma brucei infection on feed intake in dwarf goats
Fever and changes in plasma zinc and iron concentrations in the goat. The effects of interferon inducers and recombinant IFN-alpha 2a
Induction of circulating tumor necrosis factor cannot be demonstrated during septicemic salmonellosis in calves.
Endotoxin and tumor necrosis factor challenges in dogs simulate the cardiovascular profile of human septic shock
Analysis of endotoxin fever in rabbits by using a monoclonal antibody to tumor necrosis factor (cachectin).
Hematologic interactions of endotoxin, tumor necrosis factor alpha (TNF alpha), interleukin 1, and adrenal hormones and the hematologic effects of TNF alpha in Corynebacterium parvum-primed rats
Association between tumour necrosis factor in serum and fatal outcome in patients with meningococcal disease
Tumor necrosis factor can induce fever in rats without activating protein breakdown in muscle or lipolysis in adipose tissue
Recombinant human tumor necrosis factor induces acute reductions in food intake and body weight in mice
Development of partial tolerance to the gastrointestinal effects of high doses of recombinant tumor necrosis factor-alpha in rodents
Anorexia during febrile conditions in dwarf goats. The effect of diazepam, flurbiprofen and naloxone
Fever and changes in plasma zinc and iron concentrations in the goat: the role of leukocytic pyrogen
Inflammation triggers hypoferremia and de novo synthesis of serum transferrin and ceruloplasmin in mice.
Zinc concentration in plasma during experimental Salmonella dublin infection and endotoxin induced fever in calves
Pentoxifylline pretreatment fails to block the acute-phase response to Escherichia coli endotoxin in dwarf goats
Changes in food intake and forestomach motility of dwarf goats by recombinant bovine cytokines (IL-1 beta, IL-2) and IFN-gamma
Pro-inflammatory cytokines in a ruminant model: pathophysiological, pharmacological, and therapeutic aspects
The cytokine response of circulating peripheral blood mononuclear cells is changed after intravenous injection of lipopolysaccharide in cattle
Tumor necrosis factor alpha and interleukin-6 have differential effects on food intake and gastric emptying in fasted rats
Inhibitors of prostaglandin synthesis do not improve food intake or body weight of tumor-bearing rats
Comparison of serum zinc levels measured by inductively coupled plasma mass spectrometry in preschool children with febrile and afebrile seizures
Pharmacological and pathophysiological modulation of food intake and forestomach motility in small ruminants
Central tumour necrosis factor-alpha mediates the early gastrointestinal motor disturbances induced by lipopolysaccharide in sheep
Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.