PMID: 8940733Nov 1, 1996Paper

Fever and neutropenia in children with malignant disease

Pediatric Hematology and Oncology
A RoguinM Berant

Abstract

Treatment of episodes of fever and neutropenia in pediatric hematology-oncology patients includes hospitalization and administration of intravenous antibiotics until the patient is afebrile and no longer neutropenic. The present analysis characterizes retrospectively febrile episodes in neutropenic pediatric hematology-oncology patients with regard to frequency of documented infections, organisms associated with these infections, efficacy of a standardized antibiotic regimen, and safety of early antibiotic discontinuation under defined conditions. A total of 149 pediatric febrile neutropenic episodes were identified during a 4-year period between 1990 and 1994. These occurred in 47 male and 19 female patients, of a mean age of 7.6 years (range 0.5-15). The most frequent diagnoses were leukemia (41% of patients), lymphoma (21%), rhabdomyosarcoma (7%), soft tissue sarcoma (5%), Ewing's sarcoma (5%), and osteosarcoma (4%). Infection was certain in 36% of febrile episodes, probable in 14%, and not determined in 50%. Patients with severe neutropenia (absolute neutrophil count < 100) had a slightly, although not significantly higher incidence of documented and probable infection (57%). Patients with solid tumor had documented infecti...Continue Reading

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Citations

May 26, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M D van de WeteringH N Caron
Apr 25, 2002·Journal of Pediatric Hematology/oncology·Kristine MadsenPhilip P Breitfeld
Dec 6, 2011·Journal of Paediatrics and Child Health·Aditi Vedi, Richard Cohn
Feb 16, 2006·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·Ann ChangKimberly Colapinto
May 22, 2007·Pediatric Blood & Cancer·Christoph HärtelChristian Schultz
Apr 25, 2016·The Cochrane Database of Systematic Reviews·Elvira C van DalenMarianne D van de Wetering
Mar 7, 2006·Pediatric Hematology and Oncology·Gulsun TezcanVolkan Hazar
May 4, 2016·Pediatric Emergency Care·Brandon C KuFran Balamuth
Feb 16, 1999·Seminars in Surgical Oncology·P W Dillon
Mar 3, 2021·Pediatric Emergency Care·Kyriaki KaravanakiSophia Polychronopoulou

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