Fever, human herpesvirus-6 (HHV-6) seroconversion, and acute rejection episodes as a function of the initial seroprevalence for HHV-6 in renal transplant recipients

Transplantation Proceedings
D Deborska-MaterkowskaM Durlik

Abstract

Human herpesvirus-6 (HHV-6) is an opportunistic viral pathogen of emerging clinical significance in immunocompromised patients. We performed a seroepidemiological survey to test the relation between seroprevalence among donors and recipients for HHV-6 at three endpoints. Before transplantation sera obtained from cadaveric donors and from potential recipients were tested for IgG antibodies against HHV-6 using an enzyme-linked immunoassay. The group of recipient sera, including samples obtained before as well as 2, 4, 12, and 48 weeks after transplantation, were tested for anti-HHV-6 IgM antibodies using an indirect immunofluorescence assay. The statistical analysis was performed with the Cox proportional hazards models. The HHV-6 seronegative group (n = 11) compared with the HHV-6 seropositive group (n = 109) showed twice the risk of HHV-6 IgM seroconversion (RR = 2.24; P < .04), with a greater risk of fever, namely 3.8, which was on the verge of statistical significance. The opposite trend toward an association with acute rejection episodes was observed among HHV-6 seronegative patients (RR = 1.81). The presence of IgG antibody in the sera of donors to IgG seropositive recipients had no association with the occurrence of IgM se...Continue Reading

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Citations

Apr 1, 2010·Seminars in Respiratory and Critical Care Medicine·Pali Dedhiya Shah, John F McDyer
Jul 8, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Foteini KoukourgianniPierre Cochat
May 15, 2007·American Journal of Nephrology·Seham MustafaMerci Mathew
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May 4, 2012·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Regina Barbosa SchroederElizete Keitel
Aug 24, 2017·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Consuelo Beatriz Correa SierraJose Florin
Feb 2, 2011·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Mustafa AltayAli Pekcan Demiroz

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