Fever induced in rats by intrahypothalamic macrophage inflammatory protein (MIP)-1 beta: role of protein synthesis

Journal of Neuroscience Research
A Fernández-AlonsoR D Myers

Abstract

The effect of macrophage inflammatory protein-1 beta (MIP-1 beta) on body temperature, following its injection into the anterior hypothalamic pre-optic area (AH/POA), was examined by a radiotelemetry system in the freely moving rat. The purpose of this study was to examine the action of an inhibitor of protein synthesis, anisomycin, on the pyrexia which follows intrahypothalamic injection of MIP-1 beta. The micro-injection of 10 to 20 pg MIP-1 beta into the AH/POA induced a dose-dependent monophasic increase in body temperature, whereas a higher dose of 25 pg of the cytokine caused a biphasic febrile response. When MIP-1 beta was heated at 70 degrees C for 30 min prior to its administration, the pyrogenic response was abolished. Pretreatment of the micro-injection site in the AH/POA with 10 micrograms anisomycin did not alter the febrile response to 25 pg MIP-1 beta given at the same site in the AH/POA. When 10 mg/kg anisomycin was administered subcutaneously, the febrile response to 25 pg MIP-1 beta injected in the AH/POA was significantly suppressed. The present results suggest that fever caused by MIP-1 beta within the cells of the AH/POA may not require the synthesis of a new protein factor; however, the de novo synthesis o...Continue Reading

References

Jan 1, 1991·Physiological Reviews·M J Kluger
Jun 1, 1990·Brain Research Bulletin·F J MiñanoR D Myers
Aug 1, 1980·The Journal of Physiology·W I CranstonY Townsend
Jan 1, 1994·Neuroscience and Biobehavioral Reviews·C W SimpsonR D Myers

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Citations

Nov 15, 2002·Brain Research Bulletin·Eva Tavares, Francisco J Miñano
Feb 1, 1996·The European Journal of Neuroscience·F J MiñanoJ A Armengol
Dec 15, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Quentin J Pittman
Aug 24, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Huifang TangHongwei Gao

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