Fever of unknown origin (FUO): de Quervain's subacute thyroiditis with highly elevated ferritin levels mimicking temporal arteritis (TA)

Heart & Lung : the Journal of Critical Care
Burke A CunhaStephanie Strollo

Abstract

Fever of unknown origin (FUO) refers to prolonged fevers of > or = 101 degrees F and that persists for > 3 weeks that remain undiagnosed after an intensive in-hospital/outpatient workup. The most common FUO categories of are infectious, neoplastic, rheumatic/inflammatory, and miscellaneous causes. Malignancies have supplanted infectious diseases as the most common cause of FUOs in the adult population. Rheumatic/inflammatory causes of FUO are relatively less common than previously because of the introduction over the years of sophisticated diagnostic tests for most rheumatic diseases. The rheumatic/inflammatory disorders that remain important causes of FUO today are those that cannot be readily diagnosed by readily available/noninvasive tests, for example, adult Still's disease and temporal arteritis (TA). In older patients with FUO, TA can be a difficult diagnosis when the characteristic findings (ie, scalp tenderness, jaw claudication) are not present. Patients with TA presenting as FUO often have only headaches that may be accompanied by bilateral jaw discomfort. Endocrine causes of FUOs are rare. The most common endocrine disorder rarely presenting as an FUO is de Quervain's subacute thyroiditis. As in TA, subacute thyroidi...Continue Reading

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Citations

May 8, 2014·International Journal of Endocrinology·Assim A AlfaddaMossaed M Alyahya
Feb 23, 2010·Infectious Disease Clinics of North America·Burke A Cunha
Sep 8, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tobias J WeismüllerChristian P Strassburg
Jun 21, 2015·The American Journal of Medicine·Burke A CunhaCheston B Cunha
Feb 24, 2018·Journal of Medical Case Reports·Chamara Dalugama
Mar 5, 2020·Journal of Gastrointestinal Cancer·Ishaan VohraMelchor Demetria
Aug 15, 2017·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Christine A Petersen, Courtney E Francis
Jul 3, 2019·La Revue de médecine interne·A JourdesA Enfrein

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