Few associations between high-sensitivity C-reactive protein and environmental factors in 4.5-year-old children

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
Kirsi MustonenPASTURE Study Group

Abstract

Low-grade inflammation in early childhood might protect from allergic diseases later in life. Our aim was to examine the effects of different environmental factors on low-grade inflammation measured with serum high-sensitivity C-reactive protein (hsCRP) at the age of 4.5 years. The high-sensitivity CRP values (n = 653) and serum-specific IgE concentrations were measured from 4.5-year-old children in rural areas in five European countries (Austria, Finland, France, Germany, and Switzerland). Children belonged to the prospective multi-center PASTURE birth cohort. Data on early and current farming environment and domestic animal exposure were collected by questionnaires. Females as well as obese or very obese children at age of 4.5 years had higher hsCRP values than males (aOR 1.84 95% CI 1.27-2.66) and healthy weight children (aOR 4.47 95% CI 1.94-10.31), respectively. Levels were lowest in the summer. Few associations were detected between hsCRP values and farm environmental factors or atopic sensitization. However, there was evidence of children with low levels of hsCRP (below the detection limit) who had increased prevalence of sensitization to inhaled and seasonal allergens. Among non-sensitized children, spending time in sta...Continue Reading

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Citations

Jan 1, 2014·Italian Journal of Pediatrics·Dani Hakimeh, Salvatore Tripodi
Jun 19, 2013·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Srimathi KannanGinger L Chew
Apr 13, 2013·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Kirsi MustonenUNKNOWN PASTURE Study Group
Jun 24, 2014·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Laura OrivuoriUNKNOWN PASTURE Study Group
Dec 3, 2014·The Journal of Allergy and Clinical Immunology·Georg LossUNKNOWN PASTURE study group
Dec 31, 2016·Journal of Clinical Periodontology·Vinay PitchikaJan Kühnisch
Dec 29, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Hiroki TeragawaShinichiro Ueda
Apr 4, 2019·International Archives of Allergy and Immunology·Bo-Yi YangJoachim Heinrich

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