Fewer Defects in the Surface Slows the Hydrolysis Rate, Decreases the ROS Generation Potential, and Improves the Non-ROS Antimicrobial Activity of MgO

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Nemanja AnicˇićDanilo Suvorov

Abstract

Magnesium oxide (MgO) is recognised as exhibiting a contact-based antibacterial activity. However, a comprehensive study of the impact of atomic-scale surface features on MgO's antibacterial activity is lacking. In this study, the nature and abundance of the native surface defects on different MgO powders are thoroughly investigated. Their impacts on the hydrolysis kinetics, antibacterial activity against Escherichia coli (ATCC 47076), Staphylococcus epidermidis and Pseudomonas aeruginosa and the reactive oxygen species (ROS) generation potential are determined and explained. It is shown that a reduction in the abundance of low-coordinated oxygen atoms on the surface of the MgO improves its resistance to both hydrolysis and antibacterial activity. The ROS generation potential, determined in-situ using a fluorescence microplate assay and electron paramagnetic resonance spectroscopy, is not an inherent property of the studied MgO, rather it is a side product of hydrolysis (only for the most highly defected MgO particles) and/or a consequence of the MgO/bacteria interaction. The evaluation of the mutual correlations of the hydrolysis, the antibacterial activity and the ROS generation, with their origin in the surface defects' pecu...Continue Reading

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Citations

Mar 26, 2021·Heliyon·Shabnam SharminOluyomi Stephen Adeyemi
Jun 19, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Proma BhattacharyaSudarsan Neogi
Oct 6, 2020·ACS Omega·Jiajia LinHuinan Hannah Liu
Jul 4, 2020·Ultrasonics Sonochemistry·Laura BonatoSergey I Nikitenko

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