Fexofenadine in pediatrics: oral tablet and suspension formulations

Expert Opinion on Pharmacotherapy
Lyndon E Mansfield

Abstract

Allergic rhinitis is a common chronic condition in children. Oral antihistamines are a first-line treatment option in allergic rhinitis and different formulations are available to aid administration to children. The tablet formulation of the second-generation antihistamine fexofenadine has established efficacy and safety in both adults and children. To aid administration in young children, a new oral suspension formulation of fexofenadine has been developed, indicated for the relief of seasonal allergic rhinitis symptoms in children aged 2-11 years and for uncomplicated skin manifestations of chronic idiopathic urticaria in children aged 6 months-11 years. Clinical studies have shown the oral suspension to have both bioequivalence with the 30 mg tablet formulation and a favorable safety and tolerability profile.

References

Dec 1, 1996·The Journal of Allergy and Clinical Immunology·F E SimonsK J Simons
May 1, 1997·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·H Milgrom, B Bender
Dec 16, 1997·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·D I BernsteinJ Mason
Mar 21, 1998·The Journal of Allergy and Clinical Immunology·R G Slavin
Dec 22, 1998·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·M S Dykewicz, S Fineman
Jan 19, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·F PaolieriM Bagnasco
Jun 29, 1999·Clinical Pharmacokinetics·F E Simons, K J Simons
Aug 12, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·I Hindmarch, Z Shamsi
Aug 12, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J MasonN Rao
Sep 7, 1999·Allergy and Asthma Proceedings·R A Settipane
Nov 7, 1999·The Journal of Allergy and Clinical Immunology·A F FinnJ Long
Jun 1, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·H S NelsonJ Mason
Jun 16, 2000·The Journal of Allergy and Clinical Immunology·D P Skoner
Jun 16, 2000·The Journal of Allergy and Clinical Immunology·G G Kay
Mar 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M TriggianiG Marone
Jul 13, 2001·The Journal of Allergy and Clinical Immunology·E O Meltzer
Jul 31, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·D F GraftJ Long
May 11, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·I HindmarchS Kimber
Apr 22, 2003·The Journal of Allergy and Clinical Immunology·Ulrich WahnErik Ruuth
May 2, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Fran Ridout, Ian Hindmarch
May 14, 2003·The Journal of Allergy and Clinical Immunology·Thomas B CasaleUNKNOWN Antihistamine Impairment Roundtable
Jul 4, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Michael A KalinerSuzanne G Meeves
Jun 24, 2004·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Eli O MeltzerErik Ruuth
Sep 2, 2004·Paediatric Drugs·William E Berger
Dec 22, 2004·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Ashok PurohitNelly Frossard
Jun 14, 2005·British Journal of Clinical Pharmacology·Tony Nunn, Julie Williams
Nov 10, 2005·The Annals of Pharmacotherapy·Matthew M MorganRobert A Nathan
Dec 22, 2006·Drugs·Jeffrey M Lehman, Michael S Blaiss
Oct 19, 2007·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Henry MilgromFrank C Hampel
Jan 29, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Frank C HampelJulius H van Bavel

❮ Previous
Next ❯

Citations

Aug 13, 2015·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Paul PotterMarcus Maurer
Jan 26, 2011·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Martin K ChurchMarcus Maurer
Jun 23, 2010·Otolaryngologia polska. The Polish otolaryngology·Jerzy Kruszewski
Nov 4, 2021·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Eli O MeltzerLuiz Lucio

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Birth Defects Research. Part A, Clinical and Molecular Teratology
Suzanne M GilboaNational Birth Defects Prevention Study
Reproductive Toxicology
Corinna Weber-Schoendorfer, Christof Schaefer
Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
Frank HampelJulius Van Bavel
© 2021 Meta ULC. All rights reserved