FGF-23 removal is improved by on-line high-efficiency hemodiafiltration compared to conventional high flux hemodialysis

Journal of Nephrology
Laure PatrierJean-Paul Cristol

Abstract

Reducing circulating levels of fibroblast growth factor-23 (FGF-23) in patients on renal replacement therapy (RRT) could appear as an appealing approach for cardiovascular events prevention. The purpose of our study was to compare the clearance of FGF-23 between high flux hemodialysis (HD) and on-line hemodiafiltration (OL-HDF) procedures. Fifty-three patients were included in the HD group while 32 patients were included in the OL-HDF group. Serum pre- and post-dialysis FGF-23 levels were measured using a 2nd generation Human FGF-23 (C-Term) ELISA kit. Mean FGF-23 reduction rates were significantly higher in OL-HDF (55.7 ± 25.2%) versus HD (36.2 ± 28.6%) groups (P=.0001), as were calculated FGF-23 clearances (P=.015) and Kt/V-FGF-23 (P=.001). Overall, post-treatment FGF-23 levels were significantly lower than pre-treatment values in both groups (P<.01). OL-HDF achieves higher FGF-23 removal over high flux HD.

Citations

Nov 26, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jelmer K HumaldaUNKNOWN NIGRAM Consortium
Jun 28, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Lotte LipsMuriel P C Grooteman
Mar 8, 2018·Clinical Journal of the American Society of Nephrology : CJASN·Bernard CanaudUNKNOWN Kidney Health Initiative HDF Workgroup
Oct 4, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Peter J BlankestijnMichiel L Bots
Mar 5, 2020·Journal of Nephrology·Annet Bouma-de Krijger, Marc G Vervloet
Apr 1, 2020·Biomolecules·Elena Rodríguez-SánchezGema Ruiz-Hurtado
Nov 16, 2018·Journal of Nephrology·Paulo Giovanni de Albuquerque SuassunaMing-Chang Hu
Jul 30, 2020·BMC Nephrology·Magid A A IbrahimRagia M Said
Dec 28, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Menso J NubéUNKNOWN HDF Pooling Project investigators

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