PMID: 9630220Jun 18, 1998Paper

FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate

Cell
Weilan YeA Rosenthal

Abstract

During development, distinct classes of neurons are specified in precise locations along the dorso-ventral and anterior-posterior axes of the neural tube. We provide evidence that intersections of Shh, which is expressed along the ventral neural tube, and FGF8, which is locally produced at the mid/hindbrain boundary and in the rostral forebrain, create induction sites for dopaminergic neurons in the midbrain and forebrain. The same intersection, when preceded by a third signal, FGF4, which is expressed in the primitive streak, defines an inductive center for hindbrain 5-HT neurons. These findings illustrate that cell patterning in the neural plate is a multistep process in which early inducers, which initially divide the neural plate into crude compartments, are replaced by multiple local organizing centers, which specify distinct neuronal cell types within these compartments.

References

Jan 1, 1992·Neuroscience·A Résibois, J H Rogers
May 1, 1990·Developmental Biology·R M Alvarado-MallartC C Lance-Jones
Oct 1, 1969·Journal of Theoretical Biology·L Wolpert
Aug 1, 1995·Current Opinion in Genetics & Development·L Bally-Cuif, M Wassef
Oct 28, 1994·Science·J L RubensteinL Puelles
Mar 7, 1996·Nature·P H CrossleyG R Martin
Jan 1, 1996·Trends in Genetics : TIG·A L Joyner
Nov 15, 1996·Science·A Lumsden, R Krumlauf
Nov 15, 1996·Science·Y Tanabe, T M Jessell
Apr 11, 1997·Science·R H ZetterströmT Perlmann
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·M P SmidtJ P Burbach
Jan 1, 1997·Annual Review of Cell and Developmental Biology·F S Walsh, P Doherty
Jan 1, 1997·Annual Review of Cell and Developmental Biology·R Harland, J Gerhart

❮ Previous
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Citations

Jul 19, 2000·Mental Retardation and Developmental Disabilities Research Reviews·S L Pomeroy, J Y Kim
Jan 9, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M J HanW S Kim
Jul 18, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·G W EaglesonJ Frideres
Aug 24, 2004·Cell and Tissue Research·Eleni Roussa, Kerstin Krieglstein
Oct 27, 2004·Cell and Tissue Research·Alexander StorchJohannes Schwarz
Sep 2, 2004·Cell and Tissue Research·Horst H SimonLavinia Alberi
Feb 19, 2009·Cell and Tissue Research·Nadja Osterberg, Eleni Roussa
Sep 16, 2008·Neurogenetics·Stormy J ChamberlainMarc Lalande
Jan 22, 2004·Archives of Medical Research·José-Manuel BaizabalLuis Covarrubias
Oct 24, 2003·Brain Research. Brain Research Reviews·Diego EchevarríaSalvador Martínez
Jun 14, 2005·Brain Research. Brain Research Reviews·Paula Alexandre, Marion Wassef
Jan 27, 2004·Brain Research. Developmental Brain Research·Robert Riddle, Jonathan D Pollock
Nov 19, 2003·European Journal of Pharmacology·Marten P SmidtJ Peter H Burbach
Nov 19, 2003·European Journal of Pharmacology·Klaus Peter LeschLise Gutknecht
Dec 9, 2003·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·H Waage-BaudetK K Sulik
Mar 8, 2005·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Michael M Scott, Evan S Deneris
Nov 20, 2003·Neuroscience and Biobehavioral Reviews·Davide ViggianoAdolfo G Sadile
Jun 25, 2003·Experimental Neurology·Hitoshi KawanoShioko Kimura
Mar 15, 2001·Brain Research. Developmental Brain Research·F C ZhouT Li
Sep 15, 2001·Brain Research. Developmental Brain Research·N D StullL Iacovitti
Feb 19, 2002·Brain Research. Developmental Brain Research·Nina TornqvistIngrid Stromberg
Jul 20, 2002·Brain Research. Developmental Brain Research·Elke Rink, Mario F Wullimann
Mar 20, 2003·Brain Research. Developmental Brain Research·Sarah Reid, Patrizia Ferretti
Mar 20, 2003·Brain Research. Developmental Brain Research·Masaru Inatani, Yu Yamaguchi
Jul 31, 2003·Brain Research. Developmental Brain Research·Feng C ZhouTing-Kai Li
Jan 30, 2002·Trends in Neurosciences·Elisa Martí, Paola Bovolenta
Jul 17, 1999·Trends in Neurosciences·C N Svendsen, A G Smith
Jun 28, 2003·Brain Research. Molecular Brain Research·Dong-Youn HwangKwang-Soo Kim
Dec 15, 2000·Progress in Neurobiology·M F Mehler, S Gokhan
May 29, 2002·Brain Research Bulletin·E Arenas
May 30, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R H WoodruffW D Richardson
May 15, 2002·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Doreen Siu Yi LeungBernhard Reuss
Nov 13, 2001·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·K P Lesch
Jan 23, 1999·Current Opinion in Cell Biology·D PanchisionR McKay
Mar 11, 1999·Current Opinion in Neurobiology·M Hynes, A Rosenthal

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