FGF and TGFβ signaling link form and function during jaw development and evolution.

Developmental Biology
Katherine C WoronowiczRichard A Schneider

Abstract

How does form arise during development and change during evolution? How does form relate to function, and what enables embryonic structures to presage their later use in adults? To address these questions, we leverage the distinct functional morphology of the jaw in duck, chick, and quail. In connection with their specialized mode of feeding, duck develop a secondary cartilage at the tendon insertion of their jaw adductor muscle on the mandible. An equivalent cartilage is absent in chick and quail. We hypothesize that species-specific jaw architecture and mechanical forces promote secondary cartilage in duck through the differential regulation of FGF and TGFβ signaling. First, we perform transplants between chick and duck embryos and demonstrate that the ability of neural crest mesenchyme (NCM) to direct the species-specific insertion of muscle and the formation of secondary cartilage depends upon the amount and spatial distribution of NCM-derived connective tissues. Second, we quantify motility and build finite element models of the jaw complex in duck and quail, which reveals a link between species-specific jaw architecture and the predicted mechanical force environment. Third, we investigate the extent to which mechanical lo...Continue Reading

Citations

Jul 20, 2019·Development·Ryan R RobertsAmy E Merrill
Aug 17, 2019·EvoDevo·Katherine C Woronowicz, Richard A Schneider
Sep 19, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xiaopeng SongLi Gao
Aug 23, 2018·Genesis : the Journal of Genetics and Development·Richard A Schneider
Oct 25, 2020·Development·Weiyi Tang, Marianne E Bronner
Dec 15, 2020·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Gabriel L GaleaPhilippa Francis-West
Feb 7, 2021·International Journal of Oral Science·Wei DuJimmy K Hu
Aug 20, 2021·Integrative Organismal Biology·M GeigerM R Sánchez-Villagra

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