FGF-FGFR Mediates the Activity-Dependent Dendritogenesis of Layer IV Neurons during Barrel Formation

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Jui-Yen HuangHui-Chen Lu

Abstract

Fibroblast growth factors (FGFs) and FGF receptors (FGFRs) are known for their potent effects on cell proliferation/differentiation and cortical patterning in the developing brain. However, little is known regarding the roles of FGFs/FGFRs in cortical circuit formation. Here we show that Fgfr1/2/3 and Fgf7/9/10/22 mRNAs are expressed in the developing primary somatosensory (S1) barrel cortex. Barrel cortex layer IV spiny stellate cells (bSCs) are the primary recipients of ascending sensory information via thalamocortical axons (TCAs). Detail quantification revealed distinctive phases for bSC dendritogenesis: orienting dendrites toward TCAs, adding de novo dendritic segments, and elongating dendritic length, while maintaining dendritic patterns. Deleting Fgfr1/2/3 in bSCs had minimal impact on dendritic polarity but transiently increased the number of dendritic segments. However, 6 d later, FGFR1/2/3 loss of function reduced dendritic branch numbers. These data suggest that FGFs/FGFRs have a role in stabilizing dendritic patterning. Depolarization of cultured mouse cortical neurons upregulated the levels of several Fgf/Fgfr mRNAs within 2 h. In vivo, within 6 h of systemic kainic acid administration at postnatal day 6, mRNA leve...Continue Reading

Citations

Jul 31, 2018·Brain : a Journal of Neurology·Joanna SzczurkowskaLaura Cancedda
Jul 31, 2020·Proceedings of the National Academy of Sciences of the United States of America·Chia-Ming LeeQuan Lin
Jun 29, 2018·International Journal of Molecular Sciences·Qi HuiXiaojie Wang
Oct 9, 2020·Development, Growth & Differentiation·Takuji Iwasato
Feb 2, 2021·Frontiers in Cellular Neuroscience·Tzu-Yang LinChi-Hon Lee
Jan 18, 2021·Current Opinion in Neurobiology·Artur Kania
Jul 16, 2021·Developmental Medicine and Child Neurology·Alexander T WilsonRobert C Tasker

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