May 3, 2005

FGF signaling in the developing endochondral skeleton

Cytokine & Growth Factor Reviews
David M Ornitz

Abstract

Mutations in fibroblast growth factor receptors (Fgfrs) are the etiology of many craniosynostosis and chondrodysplasia syndromes in humans. The phenotypes associated with these human syndromes and the phenotypes resulting from targeted mutagenesis in the mouse have defined essential roles for FGF signaling in both endochondral and intramembranous bone development. In this review, I will focus on the role of FGF signaling in chondrocytes and osteoblasts and how FGFs regulate the growth and development of endochondral bone.

  • References96
  • Citations167

References

  • References96
  • Citations167

Citations

Mentioned in this Paper

Bone Development
Thanatophoric Dysplasia, TYPE I (Disorder)
Bone Diseases, Developmental
Craniosynostosis
Biochemical Pathway
Chondrodysplasia
Crouzon Syndrome With Acanthosis Nigricans (Disorder)
FGF7 protein, human
Fibroblast Growth Factor Receptor 1
SOX9 gene

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