May 3, 2005

FGF signaling in the developing endochondral skeleton

Cytokine & Growth Factor Reviews
David M Ornitz


Mutations in fibroblast growth factor receptors (Fgfrs) are the etiology of many craniosynostosis and chondrodysplasia syndromes in humans. The phenotypes associated with these human syndromes and the phenotypes resulting from targeted mutagenesis in the mouse have defined essential roles for FGF signaling in both endochondral and intramembranous bone development. In this review, I will focus on the role of FGF signaling in chondrocytes and osteoblasts and how FGFs regulate the growth and development of endochondral bone.

  • References96
  • Citations167


  • References96
  • Citations167


Mentioned in this Paper

Bone Development
Thanatophoric Dysplasia, TYPE I (Disorder)
Bone Diseases, Developmental
Biochemical Pathway
Crouzon Syndrome With Acanthosis Nigricans (Disorder)
FGF7 protein, human
Fibroblast Growth Factor Receptor 1
SOX9 gene

Related Feeds


Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.


Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.