FGF Signaling Pathway: A Key Regulator of Stem Cell Pluripotency

Frontiers in Cell and Developmental Biology
Majid Mossahebi-MohammadiXiaokun Li

Abstract

Pluripotent stem cells (PSCs) isolated in vitro from embryonic stem cells (ESCs), induced PSC (iPSC) and also post-implantation epiblast-derived stem cells (EpiSCs) are known for their two unique characteristics: the ability to give rise to all somatic lineages and the self-renewal capacity. Numerous intrinsic signaling pathways contribute to the maintenance of the pluripotency state of stem cells by tightly controlling key transcriptional regulators of stemness including sex determining region Y box 2 (Sox-2), octamer-binding transcription factor (Oct)3/4, krueppel-like factor 4 (Klf-4), Nanog, and c-Myc. Signaling by fibroblast growth factor (FGF) is of critical importance in regulating stem cells pluripotency. The FGF family is comprised of 22 ligands that interact with four FGF receptors (FGFRs). FGF/FGFR signaling governs fundamental cellular processes such as cell survival, proliferation, migration, differentiation, embryonic development, organogenesis, tissue repair/regeneration, and metabolism. FGF signaling is mediated by the activation of RAS - mitogen-activated protein kinase (MAPK), phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)-AKT, Phospholipase C Gamma (PLCγ), and signal transducers and activators of trans...Continue Reading

References

Jan 1, 1992·Advances in Cancer Research·C Basilico, D Moscatelli
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G R Martin
Nov 6, 1998·Science·J A ThomsonJ M Jones
May 14, 2004·Journal of Chromatography. a·Peter DePhillips, Abraham M Lenhoff
Oct 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Marcela Guzman-AyalaDaniel B Constam
Sep 24, 2005·Journal of Cell Science·Ludovic VallierRoger A Pedersen
Jan 3, 2006·Nature Biotechnology·Tenneille E LudwigJames A Thomson
Mar 7, 2006·Developmental Cell·Wentian YangBenjamin G Neel
Jun 29, 2007·Nature·I Gabrielle M BronsLudovic Vallier
Nov 22, 2007·Science·Junying YuJames A Thomson
Mar 13, 2008·Cells, Tissues, Organs·Sebastian DieckeDaniel Besser
May 24, 2008·Nature·Qi-Long YingAustin Smith
May 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jiaxi ZhouFei Wang
Jun 6, 2009·Cell Stem Cell·Jennifer Nichols, Austin Smith
Dec 18, 2009·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Angie Rizzino
May 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jacob HannaRudolf Jaenisch
May 28, 2010·Journal of Cellular Physiology·Vanessa M Y DingAndre B H Choo
Aug 4, 2010·Immunology and Cell Biology·Yuta InamiKen-Ichi Isobe
Sep 30, 2010·Development·Fredrik Lanner, Janet Rossant
Dec 9, 2010·Development·Jennifer Nichols, Austin Smith
Feb 26, 2011·Journal of Tissue Engineering·Ye-Rang YunHae-Won Kim
Mar 19, 2011·Cell·Richard A Young
Apr 12, 2011·Nature Methods·Guokai ChenJames A Thomson
Jul 6, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Kun XueHuck-Hui Ng
Jun 7, 2014·Cell Stem Cell·Thorold W Theunissen, Rudolf Jaenisch

❮ Previous
Next ❯

Citations

May 28, 2020·Frontiers in Cell and Developmental Biology·Mei-Yu QuanJin-San Zhang
Jun 19, 2020·Animals : an Open Access Journal From MDPI·Xiaoyang LvJinyu Wang
Nov 12, 2020·Genes·Michaela D Schotanus, Eric Van Otterloo
Feb 25, 2021·Stem Cell Reviews and Reports·Vijay V VishnuP Chandra Shekar
Mar 2, 2021·Frontiers in Cell and Developmental Biology·Chengyi MaoYong Yuan
Mar 9, 2021·Frontiers in Cellular Neuroscience·Anna Maria TolomeoNicola Elvassore
Mar 13, 2021·Frontiers in Cell and Developmental Biology·Giuseppina MastrototaroAlessandro Sessa
Jun 12, 2021·Stem Cell Reviews and Reports·Naira Caroline Godoy PieriAndré Furugen Cesar de Andrade
Aug 8, 2021·Journal of Clinical Medicine·Lionel Larribère, Jochen Utikal
Sep 21, 2021·Advanced Healthcare Materials·Austen L MichalakKamil Godula
Oct 13, 2021·Journal of Cellular and Molecular Medicine·Wenkai LiChi Liu

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear translocation

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.