FGF signaling refines Wnt gradients to regulate the patterning of taste papillae

Development
Michaela ProchazkovaOphir D Klein

Abstract

The patterning of repeated structures is a major theme in developmental biology, and the inter-relationship between spacing and size of such structures is an unresolved issue. Fungiform papillae are repeated epithelial structures that house taste buds on the anterior tongue. Here, we report that FGF signaling is a crucial regulator of fungiform papillae development. We found that mesenchymal FGF10 controls the size of the papillary area, while overall patterning remains unchanged. Our results show that FGF signaling negatively affects the extent of canonical Wnt signaling, which is the main activation pathway during fungiform papillae development; however, this effect does not occur at the level of gene transcription. Rather, our experimental data, together with computational modeling, indicate that FGF10 modulates the range of Wnt effects, likely via induction of Sostdc1 expression. We suggest that modification of the reach of Wnt signaling could be due to local changes in morphogen diffusion, representing a novel mechanism in this tissue context, and we propose that this phenomenon might be involved in a broader array of mammalian developmental processes.

References

Jun 1, 1990·Physiology & Behavior·I J Miller, F E Reedy
Dec 1, 1994·Physiology & Behavior·L M BartoshukI J Miller
Jan 1, 1993·Methods in Enzymology·D G Wilkinson, M A Nieto
Nov 7, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·P KettunenI Thesleff
Jul 27, 2001·Mechanisms of Development·H MiuraA Hino
Dec 20, 2002·Connective Tissue Research·M PeterkaR Peterková
Mar 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Silvia MarettoStefano Piccolo
Mar 22, 2003·Developmental Biology·Joshua M H HallThomas E Finger
May 31, 2003·Journal of Cell Science·Yoshiaki Kawano, Robert Kypta
Aug 6, 2003·Development·Nobue ItasakiRobb Krumlauf
Dec 8, 2004·Developmental Biology·Hong-Xiang LiuCharlotte M Mistretta
May 3, 2005·Cytokine & Growth Factor Reviews·Moosa MohammadiOmar A Ibrahimi
May 26, 2005·Journal of Dental Research·B HuH Lesot
Sep 24, 2005·Science·Yoshiaki KassaiNobuyuki Itoh
Jul 11, 2006·Developmental Biology·Yanqiu ZhouCharlotte M Mistretta
Nov 28, 2006·Nature Genetics·Fei LiuSarah E Millar
Feb 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ken IwatsukiRobert F Margolskee
Feb 9, 2007·Archives of Histology and Cytology·Charlotte M Mistretta, Hong-Xiang Liu
Sep 4, 2007·Developmental Biology·Sonia Guidato, Nobue Itasaki
Aug 30, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Hong-Xiang LiuCharlotte M Mistretta
Apr 14, 2009·Development·Shoba ThirumangalathuLinda A Barlow
Jun 26, 2009·The Journal of Biological Chemistry·Katherine B LinternNobue Itasaki
Jan 13, 2010·Cold Spring Harbor Perspectives in Biology·Dong Yan, Xinhua Lin
Aug 11, 2010·The Journal of Cell Biology·Nirupa Chaudhari, Stephen D Roper
Oct 26, 2011·Developmental Biology·Hong-Xiang LiuCharlotte M Mistretta
May 15, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Michaela RothovaAbigail S Tucker
Nov 28, 2012·Seminars in Cell & Developmental Biology·Marika Kapsimali, Linda A Barlow
Aug 7, 2013·Developmental Biology·Hong Xiang LiuCharalotte M Mistretta
Feb 11, 2015·Current Topics in Developmental Biology·Youngwook Ahn

❮ Previous
Next ❯

Citations

Oct 31, 2019·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Paige M DrakeTamara A Franz-Odendaal
Oct 16, 2018·International Journal of Molecular Medicine·Guanghui ChenJianru Xiao
Jan 11, 2020·Frontiers in Cell and Developmental Biology·Yu-Qing LvSaverio Bellusci
Dec 7, 2018·Frontiers in Genetics·Michaela ProchazkovaOphir D Klein
Dec 17, 2020·Developmental Biology·Wenxin YuHong-Xiang Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

CZI Human Cell Atlas Seed Network

The aim of the Human Cell Atlas (HCA) is to build reference maps of all human cells in order to enhance our understanding of health and disease. The Seed Networks for the HCA project aims to bring together collaborators with different areas of expertise in order to facilitate the development of the HCA. Find the latest research from members of the HCA Seed Networks here.

Related Papers

The International Journal of Developmental Biology
Han-Sung JungJae-Young Kim
Proceedings of the National Academy of Sciences of the United States of America
Ken IwatsukiRobert F Margolskee
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
N ChenJ R Zuniga
© 2022 Meta ULC. All rights reserved