Fgf signaling regulates development and transdifferentiation of hair cells and supporting cells in the basilar papilla.

Hearing Research
Bonnie E JacquesMatthew W Kelley

Abstract

The avian basilar papilla (BP) is a likely homolog of the auditory sensory epithelium of the mammalian cochlea, the organ of Corti. During mammalian development Fibroblast growth factor receptor-3 (Fgfr3) is known to regulate the differentiation of auditory mechanosensory hair cells (HCs) and supporting cells (SCs), both of which are required for sound detection. Fgfr3 is expressed in developing progenitor cells (PCs) and SCs of both the BP and the organ of Corti; however its role in BP development is unknown. Here we utilized an in vitro whole organ embryonic culture system to examine the role of Fgf signaling in the developing avian cochlea. SU5402 (an antagonist of Fgf signaling) was applied to developing BP cultures at different stages to assay the role of Fgf signaling during HC formation. Similar to the observed effects of inhibition of Fgfr3 in the mammalian cochlea, Fgfr inhibition in the developing BP increased the number of HCs that formed. This increase was not associated with increased proliferation, suggesting that inhibition of the Fgf pathway leads to the direct conversion of PCs or supporting cells into HCs, a process known as transdifferentiation. This also implies that Fgf signaling is required to prevent the ...Continue Reading

References

Dec 15, 1991·The Journal of Comparative Neurology·J S Stone, D A Cotanche
Dec 22, 1991·The Journal of Comparative Neurology·S BartolamiG Richardson
Mar 1, 1989·The Journal of Comparative Neurology·A Katayama, J T Corwin
Jun 24, 1988·Science·J T Corwin, D A Cotanche
Feb 1, 1993·Developmental Biology·K PetersL Williams
Jun 21, 1996·The Journal of Biological Chemistry·D M OrnitzM Goldfarb
Jun 12, 1999·Science·N A BerminghamH Y Zoghbi
Feb 8, 2000·The Journal of Comparative Neurology·J S Stone, E W Rubel
Jan 11, 2002·Developmental Biology·O Bermingham-McDonoghE W Rubel
Mar 30, 2002·Brain Research Bulletin·Hortensia Sánchez-CalderónMatías Hidalgo-Sánchez
Apr 30, 2003·The Journal of Comparative Neurology·Jennifer S StoneStanislav Tomarev
May 23, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sarah PauleyBernd Fritzsch
Aug 26, 2004·Developmental Biology·Ulla PirvolaJukka Ylikoski
Sep 17, 2004·Journal of Neuroscience Research·David W RobersonDouglas A Cotanche
Oct 7, 2004·Gene Expression Patterns : GEP·Hortensia Sánchez-CalderónMatías Hidalgo-Sánchez
Nov 16, 2004·Nature Neuroscience·Chad WoodsMatthew W Kelley
Dec 13, 2005·Trends in Cell Biology·Jacqueline M MasonJonathan D Licht
Feb 7, 2006·Developmental Biology·Cristina PujadesFernando Giraldez
Nov 23, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Toshinori HayashiOlivia Bermingham-McDonogh
May 31, 2007·The Journal of Comparative Neurology·Joana NevesFernando Giraldez
Jul 20, 2007·Development·Bonnie E JacquesMatthew W Kelley
Sep 25, 2007·The International Journal of Developmental Biology·Thomas Schimmang
Sep 25, 2007·The International Journal of Developmental Biology·Jennifer S Stone, Douglas A Cotanche
Nov 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Snezana LevicEbenezer N Yamoah
Feb 29, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eva Y MaDavid W Raible
Jun 6, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Toshinori HayashiOlivia Bermingham-McDonogh
Nov 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Alain DabdoubMatthew W Kelley
Feb 19, 2010·Journal of the Association for Research in Otolaryngology : JARO·Jialin ShangJennifer Stone
May 5, 2010·Hearing Research·Douglas A Cotanche, Christina L Kaiser
Nov 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Takahiro OhyamaAndrew K Groves
Mar 23, 2011·Developmental Biology·Norio YamamotoMatthew W Kelley

❮ Previous
Next ❯

Citations

Apr 3, 2013·Seminars in Cell & Developmental Biology·Guoqiang WanJennifer S Stone
Oct 4, 2014·Development, Growth & Differentiation·Dana HorakovaMarcela Buchtova
Jul 17, 2015·Birth Defects Research. Part A, Clinical and Molecular Teratology·Michael Melnick, Tina Jaskoll
Jan 26, 2013·Hearing Research·Elyssa L Monzack, Lisa L Cunningham
Jun 29, 2016·PloS One·Sang Goo LeeZheng-Yi Chen
Jan 1, 2012·Cells·Benjamin Kopecky, Bernd Fritzsch
May 23, 2014·Nature Communications·Zoë F MannMatthew W Kelley
Jul 22, 2014·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Mark E Lush, Tatjana Piotrowski
Apr 29, 2016·BMC Genomics·Sabrina RiccardiBernd Kinzel
Nov 3, 2020·Neural Plasticity·Yurong MuDan Li
Apr 9, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Bruce B Riley

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.