FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment

Development
Tilo KunathAustin Smith

Abstract

Pluripotent embryonic stem (ES) cells must select between alternative fates of self-replication and lineage commitment during continuous proliferation. Here, we delineate the role of autocrine production of fibroblast growth factor 4 (Fgf4) and associated activation of the Erk1/2 (Mapk3/1) signalling cascade. Fgf4 is the major stimulus activating Erk in mouse ES cells. Interference with FGF or Erk activity using chemical inhibitors or genetic ablations does not impede propagation of undifferentiated ES cells. Instead, such manipulations restrict the ability of ES cells to commit to differentiation. ES cells lacking Fgf4 or treated with FGF receptor inhibitors resist neural and mesodermal induction, and are refractory to BMP-induced non-neural differentiation. Lineage commitment potential of Fgf4-null cells is restored by provision of FGF protein. Thus, FGF enables rather than antagonises the differentiation activity of BMP. The key downstream role of Erk signalling is revealed by examination of Erk2-null ES cells, which fail to undergo either neural or mesodermal differentiation in adherent culture, and retain expression of pluripotency markers Oct4, Nanog and Rex1. These findings establish that Fgf4 stimulation of Erk1/2 is an...Continue Reading

Citations

Jun 6, 2008·Cellular and Molecular Life Sciences : CMLS·L A Davis, N I Zur Nieden
May 2, 2012·Cellular and Molecular Life Sciences : CMLS·Timothy J Stuhlmiller, Martín I García-Castro
Jun 4, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Morag H StewartMickie Bhatia
Dec 25, 2009·In Vitro Cellular & Developmental Biology. Animal·Yohei HayashiMakoto Asashima
Feb 17, 2010·International Journal of Hematology·Shinji Masui
Dec 12, 2012·Cell Research·Jia-Chi Yeo, Huck-Hui Ng
May 5, 2011·Nature Cell Biology·Huck-Hui Ng, M Azim Surani
Jun 17, 2008·Nature Methods·Kristin AlbertiPeter W Zandstra
May 16, 2013·Nature Reviews. Molecular Cell Biology·Patrick Cahan, George Q Daley
Nov 9, 2007·Gene Therapy·Satoshi Ohtsuka, Stephen Dalton
Dec 18, 2013·Biologie aujourd'hui·Pierluigi Scerbo, Laurent Coen
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Lingjie LiYing Jin
Jan 5, 2012·Proceedings of the National Academy of Sciences of the United States of America·Laralynne Przybyla, Joel Voldman
Mar 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Yi-Shin LaiTim M Townes
Oct 2, 2013·Proceedings of the National Academy of Sciences of the United States of America·Anna N MelidoniJohn McCafferty
Dec 22, 2009·The Journal of Biological Chemistry·Daniel C KraushaarLianchun Wang
Feb 3, 2012·The Journal of Biological Chemistry·Maud ForsbergKarin Forsberg-Nilsson
Dec 7, 2011·The Journal of Experimental Medicine·Bart A WestermanMaarten van Lohuizen
May 21, 2011·Stem Cells and Development·Jee-Eun JungKyung-Soon Park
May 19, 2012·Stem Cells and Development·Lan T H DangVincent Tropepe
Dec 25, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yi-Chin Toh, Joel Voldman
Oct 12, 2012·Journal of the Royal Society, Interface·Yang LuoLorenz Wernisch
Jul 6, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Thorold W Theunissen, José C R Silva
Jul 6, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Kun XueHuck-Hui Ng
Jul 6, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Rodrigo Osorno, Ian Chambers
Aug 18, 2009·Genes & Development·Taeko KobayashiRyoichiro Kageyama
Dec 31, 2009·Development, Growth & Differentiation·Fabrice Lavial, Bertrand Pain
Jan 19, 2010·Development, Growth & Differentiation·Norito ShibataKiyokazu Agata
Feb 13, 2010·Development, Growth & Differentiation·Hitoshi Niwa
Apr 7, 2010·The Journal of Clinical Investigation·Katie Cockburn, Janet Rossant
May 1, 2010·Journal of Biomedical Science·Ching-Wen ChenHong-Lin Su
Oct 28, 2010·Development·Karel Dorey, Enrique Amaya
Nov 5, 2011·The Journal of Reproduction and Development·Akifumi KandaEiso Hiyama
Dec 21, 2010·PLoS Computational Biology·Raamesh DeshpandeChad L Myers
Apr 15, 2011·PLoS Genetics·Kathryn BlairAustin Smith
Aug 11, 2011·PloS One·Katarina BlagovicJoel Voldman
Dec 18, 2013·PloS One·Christoffer TammCecilia Annerén
Mar 20, 2014·PloS One·Maria HerbergIngo Roeder
Feb 2, 2013·Biological Chemistry·Daniel C KraushaarLianchun Wang
Mar 17, 2009·Experimental & Molecular Medicine·Byoung-San MoonKang-Yell Choi
Sep 24, 2013·Antioxidants & Redox Signaling·Magdalena KozakowskaAlicja Jozkowicz
Oct 24, 2013·Stem Cells and Development·Seyedeh-Nafiseh HassaniHossein Baharvand
Apr 25, 2012·Annual Review of Analytical Chemistry·Laralynne Przybyla, Joel Voldman
Mar 27, 2012·Annual Review of Biochemistry·Marion Dejosez, Thomas P Zwaka
May 9, 2014·Trends in Biochemical Sciences·Fumio Nakaki, Mitinori Saitou
Apr 8, 2010·EMBO Molecular Medicine·Austin Smith
Mar 20, 2014·Cellular and Molecular Life Sciences : CMLS·Giuseppe LupoFederico Cremisi
Jul 7, 2014·International Orthopaedics·Yoshihiro DogakiMasahiro Kurosaka
May 6, 2014·Cellular and Molecular Life Sciences : CMLS·Jérôme Artus, Claire Chazaud
Oct 8, 2014·Annual Review of Cell and Developmental Biology·Graziano Martello, Austin Smith
Oct 29, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Tuzer Kalkan, Austin Smith
Oct 29, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Thorsten Boroviak, Jennifer Nichols
Jan 1, 2012·Cell Regeneration·Jolene Ooi, Pentao Liu
Dec 16, 2011·Stem Cell Research·J D HalleyAustin Smith
Oct 4, 2014·Cell Stem Cell·Jamie A Hackett, M Azim Surani
Jan 12, 2016·Experimental Hematology·Xinwei MaLingyi Chen
Oct 21, 2015·Proceedings of the National Academy of Sciences of the United States of America·Haixia ChenLingyi Chen
Jan 23, 2016·Wiley Interdisciplinary Reviews. Developmental Biology·Stephen FrankenbergMarilyn B Renfree
Apr 23, 2015·Proceedings of the National Academy of Sciences of the United States of America·Claudia CattoglioRobert Tjian
Oct 12, 2012·Experimental Cell Research·Zhongwei Li, Ye-Guang Chen
Jun 8, 2013·Protein & Cell·Wenfeng ZengWei Liang
Oct 11, 2011·Current Opinion in Cell Biology·Alfonso Martinez Arias, Joshua M Brickman
Feb 19, 2011·Differentiation; Research in Biological Diversity·Astrid Gillich, Katsuhiko Hayashi
Dec 30, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Beibei ZhaiZhengfeng Yin
Jul 16, 2014·Journal of the American Chemical Society·Mia L HuangKamil Godula
Jan 23, 2016·Stem Cells International·Luca FagnocchiAlessio Zippo
Jan 23, 2016·Stem Cells International·Antonio Romito, Gilda Cobellis
Apr 11, 2009·Current Opinion in Genetics & Development·Mareike Albert, Antoine H F M Peters
Nov 4, 2015·Stem Cell Reports·In Kyoung MahFrancesca V Mariani
Jan 16, 2016·Stem Cells International·Clair E WeidgangMartin Mueller
Jul 18, 2015·Current Opinion in Genetics & Development·Xingliang ZhouQi-Long Ying
Jul 21, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Vanessa J HallPoul Hyttel
Jun 23, 2009·Stem Cells·Timothy M LavauteSu-Chun Zhang
Sep 16, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Nobuyoshi KosakaTakahiro Ochiya
Jul 12, 2008·Journal of Neuroscience Research·Hideyuki MigitaKazuhiro Sakurada
Oct 8, 2008·Genesis : the Journal of Genetics and Development·Laura Batlle-MoreraJennifer Nichols
Apr 21, 2012·British Journal of Pharmacology·Stuart P AtkinsonLyle Armstrong
Oct 10, 2013·Molecular Systems Biology·Silvia Muñoz DescalzoAlfonso Martinez Arias
Aug 18, 2010·Stem Cells·Jared SterneckertHans R Schöler
Apr 11, 2012·Genes, Chromosomes & Cancer·Daniel NettersheimHubert Schorle
Oct 3, 2015·Cell Stem Cell·Aleksandra A KolodziejczykSarah A Teichmann
Sep 28, 2010·Stem Cells·Hsuan-Hwai LinYuh-Man Sun
Dec 25, 2010·Angewandte Chemie·Costas A LyssiotisPeter G Schultz
Aug 15, 2012·Biotechnology Journal·Vassiliki Nikoletopoulou, Nektarios Tavernarakis
Apr 17, 2013·Biotechnology and Applied Biochemistry·Leyla GasimliJonathan S Dordick
Nov 17, 2011·The EMBO Journal·Boris GreberHans R Schöler
Mar 23, 2011·Stem Cells·Elisa A CasanovaPaolo Cinelli
Feb 11, 2011·Stem Cells·Claire E PickfordCatherine L R Merry
Jun 15, 2013·EMBO Reports·Kyle M Loh, Bing Lim
Mar 22, 2016·Stem Cell Reports·Yoko Nakai-Futatsugi, Hitoshi Niwa
Oct 10, 2012·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Sophia L B OliveiraHenning Ulrich
Sep 10, 2013·Wiley Interdisciplinary Reviews. Developmental Biology·Mohammad Zeeshan OzairAli H Brivanlou
Jun 8, 2012·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Meng Amy Li, Lin He
Apr 12, 2012·EMBO Reports·Jordi Casanova
Jun 16, 2010·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Taeko Kobayashi, Ryoichiro Kageyama
Feb 19, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Bastian MühlKarin Bundschu
Jul 8, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yan LiRenny T Franceschi
Dec 21, 2013·Cell Proliferation·C Laestander, W Engström
Sep 12, 2013·Stem Cells·Brian DeVealeDerek van der Kooy
Mar 26, 2010·Journal of Cellular Biochemistry·Santiago Nahuel VillegasJoshua M Brickman
Feb 25, 2015·Development, Growth & Differentiation·Ke TangNaihe Jing
May 1, 2015·Cell Cycle·Mehdi PirouzMichael Kessel
Nov 14, 2015·Annual Review of Cell and Developmental Biology·Stefan Semrau, Alexander van Oudenaarden
Jan 22, 2015·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Maria HerbergIngo Roeder
Dec 6, 2014·Angewandte Chemie·Abigail PulsipherLinda C Hsieh-Wilson
Jul 29, 2011·The Biochemical Journal·Hiroyuki HiraiNobuaki Kikyo
Mar 25, 2011·Biochemical Society Transactions·Melanie J WelhamHeather Bone
Feb 13, 2010·Developmental Biology·Malkiel A CohenBenjamin E Reubinoff
Sep 25, 2012·Neuron·Xiaoyan LiWilliam D Snider
Jul 11, 2015·Reproductive Medicine and Biology·Masaki Kinoshita
Dec 24, 2014·Cell Reports·William B Hamilton, Joshua M Brickman
Jun 9, 2015·Cellular Reprogramming·Margot Van der JeughtBjörn Heindryckx
Jun 7, 2014·Cell Stem Cell·Christa BueckerJoanna Wysocka
Jun 7, 2014·Cell Stem Cell·Jia-Chi YeoHuck-Hui Ng
May 1, 2012·Cell·Hendrik MarksHendrik G Stunnenberg
Mar 16, 2011·Mechanisms of Development·Masahiro ShinGuojun Sheng
Jan 29, 2014·JAK-STAT·Yong Tang, Xiuchun Cindy Tian
Sep 1, 2014·Current Opinion in Genetics & Development·Shoudong YeQi-Long Ying
Oct 8, 2013·Biochimica Et Biophysica Acta·Hendrik Marks, Hendrik G Stunnenberg
Dec 17, 2011·Developmental Cell·Stephen FrankenbergClaire Chazaud
Jan 18, 2015·Cellular and Molecular Life Sciences : CMLS·Guanyi HuangQi-Long Ying
Oct 23, 2008·Cell Stem Cell·Gillian M MorrisonJoshua M Brickman
Feb 12, 2013·Cell Reports·Owen R DaviesSally Lowell
Apr 9, 2011·Cell Stem Cell·Kyle M Loh, Bing Lim
Jul 3, 2008·Cell Stem Cell·N Ray Dunn
Jun 6, 2009·Cell Stem Cell·Jennifer Nichols, Austin Smith
Feb 26, 2008·Cell·Janet Rossant
Feb 26, 2008·Cell·Jose Silva, Austin Smith
Jun 10, 2014·Seminars in Cell & Developmental Biology·Fumiko ItohKohei Miyazono
Nov 6, 2012·Developmental Biology·Kun ZhangJesse Mager
Dec 3, 2014·Developmental Biology·Adam F LaingJoshua M Brickman
May 31, 2016·Stem Cells International·Piya PrajumwongsParinya Noisa
May 20, 2016·Cell Death & Disease·L RinaldiA Feliciello
Jun 18, 2016·Developmental Biology·In Kyoung MahFrancesca V Mariani
Aug 9, 2016·Cell Reports·Charles A C WilliamsGreg M Findlay
Jul 1, 2016·Proteomics·Patrick S StumpfBen D MacArthur
Sep 9, 2016·Stem Cell Research·Marta GrabiecYuh-Man Sun
Oct 7, 2016·Glycoconjugate Journal·Tadahisa Mikami, Hiroshi Kitagawa
Oct 8, 2016·Molecular Neurodegeneration·Harun Najib NoristaniFlorence Evelyne Perrin
Oct 13, 2016·Cell Reports·Eric O WilliamsLeonard Guarente
Nov 1, 2016·Glycoconjugate Journal·Shoko Nishihara
Nov 7, 2016·Biochemical and Biophysical Research Communications·Thiranut JaroonwitchawanParinya Noisa
Jan 4, 2017·Nature Reviews. Genetics·Mo Li, Juan Carlos Izpisua Belmonte
Nov 12, 2016·Cold Spring Harbor Perspectives in Biology·Kunxin Luo
Apr 16, 2017·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Ying YanYangming Wang
Sep 24, 2016·Balsaeng'gwa saengsig·Jae-Young LeeKyung-Soon Park
Jan 26, 2017·Journal of Molecular Biology·Maxime BodakConstance Ciaudo
Dec 26, 2016·Journal of Molecular Biology·Joerg Betschinger
May 26, 2017·Stem Cells and Development·Ludovic ZimmerlinElias T Zambidis
Apr 5, 2017·Scientific Reports·Styliani KontogeorgakiBen D MacArthur
Jan 22, 2017·Cold Spring Harbor Perspectives in Biology·Alan C Mullen, Jeffrey L Wrana
Apr 25, 2012·Cell Transplantation·Iwona GrabowskaMaria A Ciemerych
Jan 1, 2010·Cancers·Ahmed Abdal DayemSsang-Goo Cho
Mar 24, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Elliot G NealCesario V Borlongan
Jan 24, 2018·Development, Growth & Differentiation·Masaki Kinoshita, Austin Smith
Apr 14, 2018·Genes & Development·Cristina Mayor-RuizOscar Fernandez-Capetillo
Aug 12, 2016·Genetics & Epigenetics·Jifang XiaoLiangqi Xie
Jan 5, 2013·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J Matthew Velkey, K Sue O'Shea
Jun 6, 2009·Journal of Leukocyte Biology·Christian R Geest, Paul J Coffer
Dec 20, 2017·ELife·Andrea CorsinottiIan Chambers
Sep 2, 2018·Journal of Cellular Biochemistry·Narges JafariMehdi Totonchi
Dec 14, 2016·Molecular and Cellular Biology·Megumi Ikeda, Fumiko Toyoshima
Jun 3, 2015·Molecular and Cellular Biology·Lluis MoreyLuciano Di Croce
Jan 8, 2011·Circulation Research·Michela NosedaMichael D Schneider
Nov 20, 2018·PloS One·Takuya AzamiMasatsugu Ema
May 24, 2008·Nature·Qi-Long YingAustin Smith
Jun 11, 2010·Nature·Martin F Pera, Patrick P L Tam
Apr 3, 2019·Nucleic Acids Research·Alessandro CherubiniLorenza Lazzari
Apr 6, 2019·Expert Review of Proteomics·Cristina SayagoJavier Munoz
Oct 23, 2008·The Journal of Biological Chemistry·Shufen WangWeizhi Ji
Feb 24, 2018·Experimental & Molecular Medicine·Sejong HuhTae-Hee Lee
May 9, 2019·Development·Julia DeathridgeJonathan R Chubb
Sep 14, 2012·The Journal of Reproduction and Development·Seiki HaraguchiTomoyuki Tokunaga
Jul 20, 2019·Development·Takuya AzamiClaire Chazaud
Jul 13, 2019·Proceedings of the National Academy of Sciences of the United States of America·Clinton A TaylorMelanie H Cobb
Dec 23, 2015·Molecular Systems Biology·Hanna L Sladitschek, Pierre A Neveu
Jul 11, 2014·Biology of Reproduction·Zachariah McLeanBjörn Oback
Mar 27, 2015·Cell Biology International·E Sacide Çağlayan, Şefik Güran
Mar 17, 2017·American Journal of Physiology. Cell Physiology·Taku KaitsukaKazuhito Tomizawa
Jul 28, 2010·Biochemical Society Transactions·Jason WrayAustin Smith
Jul 7, 2019·Scientific Reports·Bhairab N SinghDaniel J Garry
Mar 10, 2020·Cellular Reprogramming·Chunxia XiongXiong Xiao
Dec 8, 2016·Oncotarget·Harun Najib Noristani, Florence Evelyne Perrin
Sep 10, 2019·Cell & Bioscience·Shaojun WangGuang-Hua Peng
Jun 27, 2018·Acta Biochimica Et Biophysica Sinica·Yingxiang LiuZekun Guo
Feb 9, 2020·Nature Communications·Sissy E WamaithaKathy K Niakan
Mar 6, 2020·Frontiers in Cell and Developmental Biology·Majid Mossahebi-MohammadiXiaokun Li
Sep 11, 2020·Nature·Amy Pandya-JonesKathrin Plath
Jan 1, 2015·JAK-STAT·Satoshi OhtsukaHitoshi Niwa
Jun 15, 2017·BMC Developmental Biology·Sophie MorganiAnna-Katerina Hadjantonakis
Jun 27, 2017·NPJ Systems Biology and Applications·Etsuo A SusakiHiroki R Ueda
Oct 25, 2017·Nature Communications·Stefan SemrauAlexander van Oudenaarden
Sep 5, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Masaki YagiYasuhiro Yamada
Nov 2, 2017·Frontiers in Integrative Neuroscience·Chieh YuLarisa M Haupt
Jul 6, 2018·Frontiers in Cell and Developmental Biology·Lamuk Zaveri, Jyotsna Dhawan
Apr 18, 2019·In Vitro Cellular & Developmental Biology. Animal·Daisuke TakekoshiHidemasa Kato
Jun 5, 2020·Journal of Experimental & Clinical Cancer Research : CR·Kenly WuputraKazunari K Yokoyama
Jul 12, 2020·Proceedings of the National Academy of Sciences of the United States of America·Toru HiratsukaFiona M Watt
Aug 29, 2017·Current Stem Cell Reports·Hanna L Sladitschek, Pierre A Neveu
Jul 29, 2017·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Stephen MeekTom Burdon
Sep 9, 2018·Nature Communications·Claudia Isabelle Keller ValsecchiAsifa Akhtar
Jul 30, 2019·Frontiers in Physiology·Rachel A ShparbergMichael B Morris
Sep 24, 2019·Frontiers in Cell and Developmental Biology·Hayk MnatsakanyanPatricia Rico
Jun 25, 2020·Nature Reviews. Molecular Cell Biology·Hugo LavoieMarc Therrien
Aug 14, 2020·Proceedings of the National Academy of Sciences of the United States of America·Carolyn Sangokoya, Robert Blelloch
Mar 15, 2020·Nature Communications·Rosalia Fernandez-AlonsoGreg M Findlay
Jul 21, 2020·Reproductive Medicine and Biology·Yayoi Toyooka
Jun 13, 2008·Clinical Science·Cecilia Annerén
Jul 5, 2012·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Aryeh WarmflashAli H Brivanlou
Nov 20, 2016·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sergio MencheroMiguel Manzanares
Dec 30, 2014·Physiological Reviews·Kyle M LohLay Teng Ang
Nov 25, 2019·Stem Cell Reviews and Reports·Gele LiuRichard G Fessler
Feb 3, 2012·Physiological Reviews·Kirsty Greenow, Alan R Clarke
Aug 21, 2019·Stem Cells International·Jungwoon LeeHaiyoung Jung
Oct 14, 2020·Journal of Assisted Reproduction and Genetics·Marta Vila-CejudoElena Ibáñez
Dec 9, 2020·Development, Growth & Differentiation·Noriaki SasaiAgnes Ong Lee Chen
Feb 2, 2021·Journal of Cellular and Molecular Medicine·Jia LiMadhavi J Rane
Nov 21, 2020·Cell Stem Cell·Henry De BellyKevin J Chalut
Oct 30, 2020·Frontiers in Cell and Developmental Biology·Adelya A Galiakberova, Erdem B Dashinimaev
Feb 25, 2021·Stem Cell Reviews and Reports·Vijay V VishnuP Chandra Shekar
Dec 4, 2020·Cell Stem Cell·Masaki KinoshitaAustin Smith
Feb 15, 2021·Development, Growth & Differentiation·Yayoi Toyooka
Mar 1, 2020·Experimental Cell Research·Adeleh TaeiHossein Baharvand
Apr 8, 2021·Stem Cells International·A S DevikaSmita Sudheer

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Fgf4 protein, mouse
Cell Differentiation Process
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