Fgf10 and Sox9 are essential for the establishment of distal progenitor cells during mouse salivary gland development

Development
Lemonia ChatzeliAbigail S Tucker

Abstract

Salivary glands are formed by branching morphogenesis with epithelial progenitors forming a network of ducts and acini (secretory cells). During this process, epithelial progenitors specialise into distal (tips of the gland) and proximal (the stalk region) identities that produce the acini and higher order ducts, respectively. Little is known about the factors that regulate progenitor expansion and specialisation in the different parts of the gland. Here, we show that Sox9 is involved in establishing the identity of the distal compartment before the initiation of branching morphogenesis. Sox9 is expressed throughout the gland at the initiation stage before becoming restricted to the distal epithelium from the bud stage and throughout branching morphogenesis. Deletion of Sox9 in the epithelium results in loss of the distal epithelial progenitors, a reduction in proliferation and a subsequent failure in branching. We demonstrate that Sox9 is positively regulated by mesenchymal Fgf10, a process that requires active Erk signalling. These results provide new insights into the factors required for the expansion of salivary gland epithelial progenitors, which can be useful for organ regeneration therapy.

References

Jun 1, 1997·Nature Genetics·D M BellK S Cheah
Aug 1, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Q ZhaoB De Crombrugghe
Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·V VasioukhinE Fuchs
Nov 4, 2000·Biochemical and Biophysical Research Communications·H OhuchiN Itoh
Feb 22, 2002·Genesis : the Journal of Genetics and Development·Ralf KistGerd Scherer
Dec 24, 2002·Neuron·Simon HippenmeyerSilvia Arber
Jan 18, 2003·Developmental Cell·Markus AffolterZena Werb
Oct 12, 2005·Developmental Biology·Bernard Thisse, Christine Thisse
Feb 3, 2007·Proceedings of the National Academy of Sciences of the United States of America·Philip A SeymourMaike Sander
Mar 6, 2007·Seminars in Cell & Developmental Biology·A S Tucker
Sep 26, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Janice L WalkerMaria A Kukuruzinska
Jul 21, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Lisa L AblerXin Sun
Apr 30, 2010·Frontiers of Oral Biology·Isabelle M A Lombaert, Matthew P Hoffman
Sep 2, 2010·Genesis : the Journal of Genetics and Development·Tsunemitsu SoedaHaruhiko Akiyama
Jan 8, 2011·Human Molecular Genetics·Antoine ReginensiAndreas Schedl
Jan 18, 2011·Trends in Molecular Medicine·James PritchettKaren Piper Hanley
Apr 14, 2011·Journal of Dental Research·J HarunagaK M Yamada
Jul 19, 2011·Development, Growth & Differentiation·Eva MatalováJan Smarda
Aug 3, 2011·Developmental Biology·Nisha PatelIsabelle Miletich
Jun 30, 2012·Nature Methods·Johannes SchindelinAlbert Cardona
Aug 10, 2012·Development·Philip A SeymourMaike Sander
Jan 1, 2012·Wiley Interdisciplinary Reviews. Developmental Biology·Wendy M KnospMatthew P Hoffman
Sep 24, 2013·Proceedings of the National Academy of Sciences of the United States of America·Daniel R ChangJichao Chen
Nov 6, 2013·Proceedings of the National Academy of Sciences of the United States of America·Briana E RockichJason R Spence
Dec 29, 2013·Stem Cell Reports·Isabelle M A LombaertMatthew P Hoffman
Apr 7, 2015·Developmental Cell·Marit H AureCatherine E Ovitt
Sep 1, 2015·Current Molecular Medicine·A J MayA S Tucker
Nov 6, 2015·Biology Open·Marcia GaeteAbigail S Tucker
Dec 3, 2015·Journal of Dental Research·T H N TeshimaA S Tucker
Nov 9, 2016·Frontiers in Physiology·Tathyane H N TeshimaAbigail S Tucker

❮ Previous
Next ❯

Citations

Apr 18, 2018·Genesis : the Journal of Genetics and Development·Elaine Emmerson, Sarah M Knox
Mar 14, 2018·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Kelsey H ElliottSamantha A Brugmann
May 6, 2020·Pathology International·Junichi Tanaka, Kenji Mishima
Aug 18, 2020·Disease Models & Mechanisms·Shohei YoshimotoShuichi Hashimoto
Dec 7, 2018·Frontiers in Genetics·Michaela ProchazkovaOphir D Klein
Jan 11, 2020·Frontiers in Cell and Developmental Biology·Yu-Qing LvSaverio Bellusci
Jan 24, 2018·Journal of Cell Science·Zeinab F HosseiniMelinda Larsen
Jul 25, 2019·Journal of Dental Research·M H AureM P Hoffman
Oct 17, 2018·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Hiroko KawakamiYasuhiko Kawakami
Oct 13, 2018·Nature Communications·Junichi TanakaKenji Mishima
Aug 29, 2019·Cells·Cristina Porcheri, Thimios A Mitsiadis
Dec 29, 2020·Frontiers in Cell and Developmental Biology·Yang ZhangAbigail S Tucker
Jan 16, 2021·Cellular and Molecular Life Sciences : CMLS·Akiko SuzukiJunichi Iwata
Jan 27, 2021·Journal of Oral Biosciences·Junichi TanakaKenji Mishima
Jan 18, 2021·Journal of Anatomy·Lemonia ChatzeliAbigail S Tucker
Jan 14, 2021·International Journal of Molecular Sciences·Junchul KimKyungpyo Park
Jan 12, 2021·Frontiers in Physiology·Elizabeth N Schock, Carole LaBonne
Sep 12, 2018·The American Journal of Pathology·Ania ProchnickiChristoph Daniel
May 13, 2021·Journal of Dental Research·C GluckR A Romano
Jun 19, 2021·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yosuke MiyachiAkira Suzuki
Nov 7, 2021·Current Osteoporosis Reports·Arvind HariharanSimon D Tran

❮ Previous
Next ❯

Software Mentioned

GraphPad Prism
ImageJ
Fiji

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.