Fgf10-positive cells represent a progenitor cell population during lung development and postnatally

Development
Elie El AghaSaverio Bellusci

Abstract

The lung mesenchyme consists of a widely heterogeneous population of cells that play crucial roles during development and homeostasis after birth. These cells belong to myogenic, adipogenic, chondrogenic, neuronal and other lineages. Yet, no clear hierarchy for these lineages has been established. We have previously generated a novel Fgf10(iCre) knock-in mouse line that allows lineage tracing of Fgf10-positive cells during development and postnatally. Using these mice, we hereby demonstrate the presence of two waves of Fgf10 expression during embryonic lung development: the first wave, comprising Fgf10-positive cells residing in the submesothelial mesenchyme at early pseudoglandular stage (as well as their descendants); and the second wave, comprising Fgf10-positive cells from late pseudoglandular stage (as well as their descendants). Our lineage-tracing data reveal that the first wave contributes to the formation of parabronchial and vascular smooth muscle cells as well as lipofibroblasts at later developmental stages, whereas the second wave does not give rise to smooth muscle cells but to lipofibroblasts as well as an Nkx2.1(-) E-Cad(-) Epcam(+) Pro-Spc(+) lineage that requires further in-depth analysis. During alveologenesi...Continue Reading

References

Dec 1, 1978·The Anatomical Record·C Vaccaro, J S Brody
Sep 19, 1998·Developmental Biology·W Y ParkW V Cardoso
May 1, 1999·Biochemical and Biophysical Research Communications·M YamasakiN Itoh
Apr 18, 2002·Genes & Development·Hiroshi SakaueNobuyuki Itoh
Jan 27, 2004·The American Journal of Pathology·Kyung U HongBarry R Stripp
May 27, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Lewis P RubinHenry M Kronenberg
Nov 24, 2004·The Journal of Biological Chemistry·Jining LüWellington V Cardoso
Jun 2, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Mie YamadaTatsuo Sakai
Oct 3, 2007·Genes & Development·R Sathish SrinivasanGuillermo Oliver
Feb 26, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Lin ShanMary E Sunday
Mar 11, 2008·Molecular and Cellular Neurosciences·Mohammad K HajihosseiniSaverio Bellusci
Oct 4, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Stephen E McGowanAmey J Holmes
Oct 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jianwen QueBrigid L M Hogan
Jul 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jason R RockBrigid L M Hogan
Feb 9, 2010·American Journal of Respiratory Cell and Molecular Biology·Aliete LangsdorfXingbin Ai
Feb 15, 2012·Stem Cells·Jonathan L McQualter, Ivan Bertoncello
Jun 2, 2012·American Journal of Respiratory Cell and Molecular Biology·Leiling ChenAnne-Karina T Perl
Jul 14, 2012·PPAR Research·Virender K Rehan, John S Torday
Sep 15, 2012·Developmental Cell·Daniel M GreifMark A Krasnow
Oct 2, 2012·The Journal of Clinical Investigation·Caterina TiozzoParviz Minoo
Apr 5, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Niels HaanMohammad K Hajihosseini
Aug 8, 2013·The Journal of Clinical Investigation·Christina E BarkauskasBrigid L M Hogan

❮ Previous
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Citations

Jun 4, 2014·Fibrogenesis & Tissue Repair·Thomas Volckaert, Stijn De Langhe
Dec 3, 2014·The International Journal of Biochemistry & Cell Biology·Jonathan L McQualterGeoffrey J Laurent
Aug 12, 2015·Journal of Biochemistry·Changgong LiParviz Minoo
Aug 16, 2014·Wiley Interdisciplinary Reviews. Developmental Biology·Jun Yang, Jichao Chen
Mar 19, 2014·Birth Defects Research. Part A, Clinical and Molecular Teratology·Stephen E McGowan
Dec 4, 2014·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Thomas Volckaert, Stijn P De Langhe
Sep 29, 2015·American Journal of Respiratory Cell and Molecular Biology·Jenna GreenAnne-Karina T Perl
Mar 22, 2015·Current Opinion in Genetics & Development·David McCulleyXin Sun
Jan 13, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jamie A Havrilak, John M Shannon
Mar 17, 2015·Wiley Interdisciplinary Reviews. Developmental Biology·David M Ornitz, Nobuyuki Itoh
Oct 16, 2015·Seminars in Cell & Developmental Biology·Elie El AghaSaverio Bellusci
Apr 22, 2016·Molecular and Cellular Pediatrics·Cho-Ming ChaoSaverio Bellusci
Oct 26, 2016·Differentiation; Research in Biological Diversity·Jessica M SwongerMichelle D Tallquist
Oct 27, 2016·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Elie El AghaSaverio Bellusci
Apr 8, 2017·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Elie El AghaSaverio Bellusci
Jan 11, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Tara M NordgrenDebra J Romberger
Jun 29, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Katharina HeinzelmannOliver Eickelberg
May 4, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Elie El AghaDjuro Kosanovic
Aug 30, 2018·Physiological Reports·Kelly A CorrellRobert J Mason
May 29, 2014·Molecular and Cellular Biology·Masahiko KanehiraMasakazu Ichinose
Nov 21, 2014·Nature Protocols·Alexander N CombesIan M Smyth
Sep 28, 2018·Pediatric Pulmonology·Lael M Yonker, T Bernard Kinane
Nov 15, 2018·Physiological Reviews·Jeffrey A WhitsettVladimir V Kalinichenko
Jan 25, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Juwon ParkMichelle D Tallquist
Feb 1, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Timo H LüdtkeAndreas Kispert
Sep 29, 2018·The European Respiratory Journal·Konstantinos GkatzisSaverio Bellusci
Aug 8, 2018·Respiratory Research·José Alberto Rodríguez-CastilloKatrin Ahlbrecht
Jun 29, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Daniel TahedlChristian Mühlfeld
Jul 4, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Stephen E McGowan, Diann M McCoy
Apr 21, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Renee F ConwayJason R Spence
Jan 16, 2020·American Journal of Respiratory Cell and Molecular Biology·Chiko Shimbori, Elie El Agha
Sep 7, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Katrin Ahlbrecht, Stephen E McGowan
Sep 6, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jordi Ruiz-Camp, Rory E Morty
Sep 2, 2017·American Journal of Respiratory Cell and Molecular Biology·Shawn K Ahlfeld, Anne Karina Perl

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