FGF6 modulates the expression of fibroblast growth factor receptors and myogenic genes in muscle cells

Experimental Cell Research
S PizetteO deLapeyrière

Abstract

Fgf6 is the only known member of the FGF family whose expression is restricted to the muscle cell lineage during development, suggesting it may have a role in myogenesis. Muscle satellite cells but not C2 myoblast cells were found to express Fgf6. We have used purified recombinant FGF6 protein to explore the effect of this factor on C2 cells in culture. FGF6 stimulated the proliferation of C2 myoblasts and, in combination with heparin, induced their morphological transformation. FGF6, added at 5 ng/ml and in the presence of heparin, increased the expression of a subset of muscle cell differentiation markers. In contrast, at 25 ng/ml, it down-regulated the expression of myogenic markers and myogenic transcription factors examined and delayed differentiation into myotubes of C2 cells. It also up-regulated the expression of FgfR1 and had an opposite effect on FgfR4. These results suggest that intramuscular FGF6 concentrations could influence the proliferation and differentiation processes taking place during development.

Citations

Aug 15, 1997·Genes & Development·T FlossT Braun
Jan 22, 2011·Sarcoma·Lisa E S Crose, Corinne M Linardic
Sep 25, 2004·Journal of Cellular Physiology·David IsraeliLuis Garcia
Jan 27, 2005·Journal of Cellular Physiology·Anne-Sophie ArmandChristophe Chanoine
May 12, 2010·Journal of Cellular Physiology·Michela BosettiMario F Cannas
Sep 3, 2013·Birth Defects Research. Part A, Clinical and Molecular Teratology·Sandeep DabSiew-Ging Gong
Jun 15, 2004·Experimental Cell Research·Anne-Sophie ArmandFrédéric Charbonnier
Jan 13, 2000·Differentiation; Research in Biological Diversity·S Düsterhöft, D Pette
Sep 16, 2003·Biochimica Et Biophysica Acta·Anne-Sophie ArmandChristophe Chanoine
Aug 1, 2006·Biochimica Et Biophysica Acta·Anne-Sophie ArmandChristophe Chanoine
May 5, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·V SogosF Gremo
Sep 11, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A YamaneH C Slavkin
Dec 19, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Z Yablonka-ReuveniA J Rivera
Jul 18, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S KästnerZ Yablonka-Reuveni
Jun 29, 2000·Biochemical and Biophysical Research Communications·F FioreD Birnbaum

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.