FGF8 isoform b expression in human prostate cancer

British Journal of Cancer
V J GnanapragasamH Y Leung

Abstract

Overexpression of fibroblast growth factor 8 (FGF8) mRNA has been previously described in prostate cancer. Of its four isoforms, FGF8b is thought to be the most important in carcinogenesis. We hypothesised that immunodetection of FGF8b in archival prostate cancer specimens is of potential prognostic value. Using a selected cohort of prostate tumours from transurethral (n=30) and radical prostatectomies (n=59), an optimised protocol for FGF8b immunoreactivity was used to corroborate expression with clinical parameters. No expression was observed in benign prostates (n=10). In prostate cancer, immunoreactivity was localised to the malignant epithelium with weak signals in the adjacent stroma. Expression of FGF8b in stage T1 and T2 cancers were 40 and 67%, respectively. In contrast, FGF8b expression was present in 94% of T3 and 100% of T4 cancers. By histological grade, FGF8b was found in 41% of low-grade cancers (Gleason score 4-6), 60% of intermediate-grade cancers (Gleason score 7 and 92% of high-grade cancers (Gleason score 8-10). The intensity of expression was significantly associated with stage (P=0.0004) and grade (P<0.0001) of disease. We further hypothesised that FGF8b overexpression resulted from enhanced transcription ...Continue Reading

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Citations

Oct 22, 2011·Cancer Metastasis Reviews·Isabelle M BerquinYong Q Chen
Nov 15, 2011·BMC Cancer·Tania ValenciaVincent J Gnanapragasam
Apr 25, 2007·DNA Sequence : the Journal of DNA Sequencing and Mapping·Kim E HaworthPaul T Sharpe
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Methods Mentioned

BETA
biopsies
PCR

Software Mentioned

Arcus QuickStat
BLAST

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