FGF9 and FGF18 in idiopathic pulmonary fibrosis promote survival and migration and inhibit myofibroblast differentiation of human lung fibroblasts in vitro

American Journal of Physiology. Lung Cellular and Molecular Physiology
Audrey JoannesArnaud A Mailleux

Abstract

Idiopathic pulmonary fibrosis (IPF) is characterized by an accumulation of extracellular matrix proteins and fibroblasts in the distal airways. Key developmental lung signaling pathways are reactivated in IPF. For instance, fibroblast growth factor 9 (FGF9) and FGF18, involved in epithelial-mesenchymal interactions, are critical for lung development. We evaluated the expression of FGF9, FGF18, and FGF receptors (FGFRs) in lung tissue from controls and IPF patients and assessed their effect on proliferation, survival, migration, and differentiation of control and IPF human lung fibroblasts (HLFs). FGF9, FGF18, and all FGFRs were present in the remodeled alveolar epithelium close to the fibroblast foci in IPF lungs. FGFR3 was generally detected in fibroblast foci by immunohistochemistry. In vitro, HLFs mainly expressed mesenchyme-associated FGFR isoforms (FGFR1c and FGFR3c) and FGFR4. FGF9 did not affect fibroblast proliferation, whereas FGF18 inhibited cell growth in control fibroblasts. FGF9 and FGF18 decreased Fas-ligand-induced apoptosis in control but not in IPF fibroblasts. FGF9 prevented transforming growth factor β1-induced myofibroblast differentiation. FGF9 and FGF18 increased the migratory capacities of HLF, and FGF9 a...Continue Reading

References

Jun 21, 1996·The Journal of Biological Chemistry·D M OrnitzM Goldfarb
May 5, 1999·American Journal of Respiratory Cell and Molecular Biology·C BecerrilM Selman
Aug 26, 2000·Cytokine & Growth Factor Reviews·B BoillyX Le Bourhis
Feb 15, 2001·Annals of Internal Medicine·M SelmanUNKNOWN American College of Chest Physicians
Mar 29, 2001·Genome Biology·D M Ornitz, N Itoh
Apr 3, 2002·The Journal of Biological Chemistry·Jeffrey A WhitsettMildred T Stahlman
Dec 24, 2002·American Journal of Respiratory Cell and Molecular Biology·Jeffrey J Atkinson, Robert M Senior
Apr 23, 2003·The American Journal of Pathology·Marco ChilosiClaudio Doglioni
Apr 26, 2003·American Journal of Respiratory Cell and Molecular Biology·Yuben P MoodleyDarryl A Knight
Jun 5, 2003·Developmental Biology·Molly WeaverBrigid L M Hogan
Feb 26, 2004·Paediatric Respiratory Reviews·David Warburton, Saverio Bellusci
Sep 1, 2004·Biochemical and Biophysical Research Communications·Hiroko UsuiNobuyuki Itoh
Feb 24, 2006·Developmental Biology·Pierre-Marie del MoralSavério Bellusci
Apr 7, 2006·The Journal of Biological Chemistry·Xiuqin ZhangDavid M Ornitz
Jun 2, 2006·Proceedings of the American Thoracic Society·Victor J Thannickal, Jeffrey C Horowitz
Jun 13, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Carlos RamosMoisés Selman
Oct 20, 2006·IUBMB Life·Yoshifumi Itoh
Jan 24, 2007·Physiological Reviews·Kendra J GreenleeFarrah Kheradmand
Aug 19, 2007·Chest·Wei ShiDavid Warburton
Sep 25, 2007·Carcinogenesis·Gudrun SonvillaMichael Grusch
Jun 6, 2008·Developmental Biology·Yongjun YinDavid M Ornitz
Jun 6, 2009·American Journal of Respiratory and Critical Care Medicine·Varsha V GupteSaverio Bellusci
Oct 21, 2009·The European Respiratory Journal·C QuesnelM Dehoux
Nov 26, 2009·Oncogene·A JoannesB Nawrocki-Raby
Sep 22, 2010·American Journal of Respiratory Cell and Molecular Biology·David H TompkinsJeffrey A Whitsett
Jun 3, 2011·The Journal of Clinical Investigation·Michael F Beers, Edward E Morrisey
Jun 29, 2011·The Journal of Experimental Medicine·Yuejuan LiPaul W Noble
Jul 2, 2011·Lancet·Talmadge E KingMoisés Selman
Sep 1, 2011·Physiological Genomics·Marie-Laure Franco-MontoyaJacques R Bourbon
May 3, 2012·Cold Spring Harbor Perspectives in Biology·David M Ornitz, Yongjun Yin
Jun 2, 2012·American Journal of Respiratory Cell and Molecular Biology·Leiling ChenAnne-Karina T Perl
Oct 2, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Alfredo Lozano BolañosMoisés Selman
Mar 19, 2013·Biochimica Et Biophysica Acta·Norihiko Sakai, Andrew M Tager
Jun 4, 2013·Nature Medicine·Denise GayGeorge Cotsarelis
Jun 26, 2013·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Emily CoffeyPhilip L Sannes
Dec 21, 2013·Cell Proliferation·C Laestander, W Engström

❮ Previous
Next ❯

Citations

Oct 21, 2016·The Journal of Pathology·Kevin K KimJeffrey C Horowitz
Oct 27, 2016·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Elie El AghaSaverio Bellusci
Jul 31, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·David N O'DwyerBethany B Moore
Aug 10, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Yuichiro HirataHiroyuki Tanaka
Nov 22, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kolene E BaileyChelsea M Magin
Jul 9, 2016·The European Respiratory Journal·Moisés SelmanAnnie Pardo
Dec 13, 2018·American Journal of Respiratory Cell and Molecular Biology·Kazuya KoyamaYasuhiko Nishioka
May 2, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jarrod W BarnesStefanie Krick
Nov 7, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Simone EbenerManuela Funke
Oct 5, 2017·Biomolecules·Pratiek N MatkarKrishna K Singh
Oct 22, 2019·American Journal of Physiology. Renal Physiology·Takeshi WakashimaMasaomi Nangaku
Nov 17, 2017·Cell Cycle·Mei-Yao HeXuesong Yang
May 6, 2020·American Journal of Respiratory Cell and Molecular Biology·Robert Guzy
Apr 28, 2020·American Journal of Respiratory Cell and Molecular Biology·Shun MorizumiYasuhiko Nishioka
Jul 22, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Aurélien JustetBruno Crestani
Oct 4, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·David E Surate SolaligueRory E Morty
Sep 19, 2019·Journal of Cell Science·Dakota L JonesDaniel J Tschumperlin
Nov 4, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Rachel G ScheragaJeffrey D Hasday
Sep 4, 2020·Signal Transduction and Targeted Therapy·Yangli XieLin Chen
May 11, 2017·The Journal of Biological Chemistry·Robert D GuzyDavid M Ornitz
Jan 11, 2021·Translational Research : the Journal of Laboratory and Clinical Medicine·Fabian A MendozaSergio A Jimenez
Nov 12, 2019·Biochemical and Biophysical Research Communications·Jiateng SunLiansheng Wang
Feb 13, 2021·The Spine Journal : Official Journal of the North American Spine Society·Hasibullah HabibiHiroaki Nakamura
Nov 20, 2020·European Respiratory Review : an Official Journal of the European Respiratory Society·Antoine FroidureArnaud Mailleux
Mar 4, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Tatjana Seitz, Claus Hellerbrand

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis