FGF/FGFR signaling pathway involved resistance in various cancer types

Journal of Cancer
Yangyang ZhouXiaojing Du

Abstract

Resistance becomes major clinical issue in cancer treatment, which strongly limits patients to benefit from oncotherapy. Growing evidences have been indicative of the critical role of fibroblast growth factor (FGF)/receptor (FGFR) signaling played in resistance to oncotherapy. In this review we discussed the underlying mechanisms of FGF/FGFR signaling mediated resistance to chemotherapy, radiotherapy and target therapy in various cancers. Meanwhile, we summarized the reported mechanism of FGF/FGFR inhibitors resistance in cancers.

Citations

Aug 6, 2020·Therapeutic Advances in Medical Oncology·Jing WangDa Li
Dec 17, 2020·Journal of Biochemical and Molecular Toxicology·Gamze Guney EskilerMurat Kasap
Feb 12, 2021·Journal of Hematology & Oncology·Sitong YueDaichao Wu
Mar 19, 2021·Cancer Treatment Reviews·Lipika GoyalJohn Bridgewater
Apr 13, 2021·Frontiers in Endocrinology·Esmael Besufikad Belachew, Dareskedar Tsehay Sewasew
May 4, 2021·Frontiers in Endocrinology·Giovanni VitaleAnnamaria Colao
May 19, 2021·European Journal of Medicinal Chemistry·Riccardo CastelliArianna Giacomini
Jul 17, 2021·Current Oncology Reports·Gentry King, Milind Javle
Jul 20, 2021·Future Oncology·Ulrik N LassenBernard Avouac

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Methods Mentioned

BETA
nuclear translocation
oncotherapy
xenograft

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