FGFR2 mutations are rare across histologic subtypes of ovarian cancer

Gynecologic Oncology
Sara A ByronPamela M Pollock

Abstract

Ovarian cancer is the leading cause of death from gynecologic malignancies in the Western world. Fibroblast growth factor receptor (FGFR) signaling has been implicated to play a role in ovarian tumorigenesis. Mutational activation of one member of this receptor family, FGFR2, is a frequent event in endometrioid endometrial cancer. Given the similarities in the histologic and molecular genetics of ovarian and endometrial cancers, we hypothesized that activating FGFR2 mutations may occur in a subset of endometrioid ovarian tumors, and possibly other histotypes. Six FGFR2 exons were sequenced in 120 primary ovarian tumors representing the major histologic subtypes. FGFR2 mutation was detected at low frequency in endometrioid (1/46, 2.2%) and serous (1/41, 2.4%) ovarian cancer. No mutations were detected in clear cell, mucinous, or mixed histology tumors or in the ovarian cancer cell lines tested. Functional characterization of the FGFR2 mutations confirmed that the mutations detected in ovarian cancer result in receptor activation. Despite the low incidence of FGFR2 mutations in ovarian cancer, the two FGFR2 mutations identified in ovarian tumors (S252W, Y376C) overlap with the oncogenic mutations previously identified in endometr...Continue Reading

References

Jun 5, 1991·Journal of the National Cancer Institute·A MonksA Vaigro-Wolff
May 1, 1997·Trends in Genetics : TIG·M K Webster, D J Donoghue
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·S C RobertsonD J Donoghue
Feb 11, 1999·American Journal of Human Genetics·M OldridgeA O Wilkie
Nov 10, 2000·International Journal of Cancer. Journal International Du Cancer·E ValveP Härkönen
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·K YuD M Ornitz
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·O A IbrahimiM Mohammadi
Nov 3, 2004·Cancer Research·Ian G CampbellWayne A Phillips
May 3, 2005·Cytokine & Growth Factor Reviews·Moosa MohammadiOmar A Ibrahimi
Dec 3, 2005·Cancer Research·Katsutoshi OdaFrank McCormick
Jun 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael J BirrerSamuel C Mok
Jun 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Amit DuttHeidi Greulich
May 29, 2009·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun

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Citations

Aug 1, 2013·Apoptosis : an International Journal on Programmed Cell Death·Kai Hung TiongChee-Onn Leong
Aug 2, 2013·International Journal of Molecular Sciences·Nikos G GavalasAristotle Bamias
Oct 24, 2013·The International Journal of Biochemistry & Cell Biology·Abbie E FearonRichard P Grose
Feb 20, 2013·The Journal of Cell Biology·Zamal AhmedJohn E Ladbury
Jul 19, 2011·Cancer Treatment Reviews·Jordan Schmitt, Daniela Matei
Sep 2, 2011·Molecular Carcinogenesis·Deepak C NagendraJohn I Risinger
May 25, 2015·Cytokine & Growth Factor Reviews·Leandro H GalloDaniel J Donoghue
Jun 30, 2011·The Biochemical Journal·Jørgen WescheEllen Margrethe Haugsten
Mar 8, 2011·Expert Opinion on Therapeutic Targets·Christine HeinzleBrigitte Marian
Dec 23, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Anthony Estienne, Christopher A Price
May 4, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Fuminori TaniguchiNaoki Terakawa
Jun 19, 2014·Molecular and Clinical Oncology·Hideaki MuraseKenichi Sugihara
Jun 20, 2013·The Journal of Clinical Investigation·Philip J StephensP Andrew Futreal
Nov 5, 2010·Molecular Cancer Research : MCR·Ellen Margrethe HaugstenJørgen Wesche

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