FGFR3 targeting strategies for achondroplasia

Expert Reviews in Molecular Medicine
Melanie B Laederich, W A Horton

Abstract

Mutations that exaggerate signalling of the receptor tyrosine kinase fibroblast growth factor receptor 3 (FGFR3) give rise to achondroplasia, the most common form of dwarfism in humans. Here we review the clinical features, genetic aspects and molecular pathogenesis of achondroplasia and examine several therapeutic strategies designed to target the mutant receptor or its signalling pathways, including the use of kinase inhibitors, blocking antibodies, physiologic antagonists, RNAi and chaperone inhibitors. We conclude by discussing the challenges of treating growth plate disorders in children.

References

Mar 1, 1994·Nature Genetics·M VelinovP Tsipouras
Jun 21, 1996·The Journal of Biological Chemistry·D M OrnitzM Goldfarb
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·M SudaK Nakao
Sep 18, 1999·Cell·A N PlotnikovM Mohammadi
Nov 26, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S GarofaloA Yayon
Feb 3, 2000·Proceedings of the National Academy of Sciences of the United States of America·S MurakamiB de Crombrugghe
Mar 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·H ChushoK Nakao
Apr 9, 2002·Genes & Development·Zhonghao LiuDavid M Ornitz
May 16, 2003·Nature·Henry M Kronenberg
Dec 31, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jay Y ChoWilliam A Horton
Apr 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Anne GorielyAndrew O M Wilkie
May 3, 2005·Cytokine & Growth Factor Reviews·Moosa MohammadiOmar A Ibrahimi
May 3, 2005·Cytokine & Growth Factor Reviews·V P EswarakumarJ Schlessinger
May 3, 2005·Cytokine & Growth Factor Reviews·David M Ornitz
May 3, 2005·Cytokine & Growth Factor Reviews·Lisa DaileyClaudio Basilico
Sep 8, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jorge Martínez-TorrecuadradaJ Ignacio Casal
Dec 29, 2005·American Journal of Medical Genetics. Part a·Chahira Kozma
Dec 31, 2005·The Journal of Clinical Endocrinology and Metabolism·Robert C OlneyMatthew L Warman
Jan 3, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ren ZhangBenoit de Crombrugghe

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Citations

Apr 8, 2014·Genes·Dianne F NewburySilvia Paracchini
Jun 16, 2015·Connective Tissue Research·Jyoti Narayana, William A Horton
Oct 8, 2015·Human Molecular Genetics·Kendra A Klag, William A Horton
Mar 17, 2015·Wiley Interdisciplinary Reviews. Developmental Biology·David M Ornitz, Nobuyuki Itoh
Jun 18, 2016·Proceedings of the National Academy of Sciences of the United States of America·Rachel RuoffVictoria Kolupaeva
Mar 17, 2017·Molecular & Cellular Proteomics : MCP·Jessica R ChapmanVictoria Kolupaeva
Apr 18, 2017·Orphanet Journal of Rare Diseases·Binbin Chen, Russ B Altman
Aug 12, 2017·Journal of Applied Physiology·Maria A Serrat, Gabriela Ion
Oct 25, 2017·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jia ChenGuixing Qiu
Dec 18, 2012·Reproduction : the Official Journal of the Society for the Study of Fertility·Manabu OzawaAlan D Ealy
Jan 23, 2013·Nature Reviews. Endocrinology·Claudia Durand, Gudrun A Rappold
May 26, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nobuyoshi KosakaTakahiro Ochiya
Jul 30, 2015·Genes & Development·David M Ornitz, Pierre J Marie

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Cell Signaling by Tyrosine Kinases

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