FHIT expression in clear cell renal carcinomas: versatility of protein levels and correlation with survival

The Journal of Pathology
U RampC D Gerharz

Abstract

Clear cell renal cell carcinomas (RCCs) are characterized by a deletion of chromosome 3p, which might result in the inactivation of the FHIT (fragile histidine triad) gene, a putative tumour suppressor gene. To explore the relevance of FHIT aberrations for tumour progression and prognosis in clear cell RCCs, FHIT protein expression was analysed in formalin-fixed tissue from 149 clear cell RCCs by immunohistochemistry. FHIT protein expression was found to be markedly reduced in all RCCs, when compared with adjacent non-neoplastic tubule epithelia. Although remaining below the FHIT levels of normal tubule epithelia, a significant increase of FHIT expression became evident from well (G1) to poorly (G3) differentiated clear cell RCCs (p=0.0001) and from low (pT1) to advanced (pT3) tumour stages (p=0.001). The log-rank test demonstrated a significant inverse correlation (p=0.0074) between FHIT expression and tumour aggressiveness as indicated by patient survival. Cox regression analysis revealed that FHIT expression is an independent prognostic parameter (p=0.0139) in clear cell RCCs. In conclusion, clear cell RCCs show a marked reduction of FHIT protein expression when compared with their putative cells of origin. In contrast to ot...Continue Reading

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Citations

Apr 3, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Rajesh KannangaiMichael Torbenson
Dec 20, 2007·Applied Immunohistochemistry & Molecular Morphology : AIMM·Huachuan ZhengYasuo Takano
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May 2, 2021·Cancer Treatment and Research Communications·N A Diez-CalzadillaJ M Martínez-Jabaloyas

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