Fhit regulates invasion of lung tumor cells

Oncogene
Audrey JoannesBéatrice Nawrocki-Raby

Abstract

In many types of cancers, the fragile histidine triad (Fhit) gene is frequently targeted by genomic alterations leading to a decrease or loss of gene and protein expression. Fhit has been described as a tumor suppressor gene because of its ability to induce apoptosis and to inhibit proliferation of tumor cells. Moreover, several studies have shown a correlation between the lack of Fhit expression and tumor aggressiveness, thus suggesting that Fhit could be involved in tumor progression. In this study, we explored the potential role of Fhit during tumor cell invasion. We first showed that a low Fhit expression is associated with in vivo and in vitro invasiveness of tumor cells. Then, we showed that Fhit overexpression in Fhit-negative highly invasive NCI-H1299 cells by transfection of Fhit cDNA and Fhit inhibition in Fhit-positive poorly invasive HBE4-E6/E7 cells by transfection of Fhit small interfering RNA induce, respectively, a decrease and an increase in migratory/invasive capacities. These changes in cell behavior were associated with a reorganization of tight and adherens junction molecules and a regulation of matrix metalloproteinase and vimentin expression. These results show that Fhit controls the invasive phenotype of...Continue Reading

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Citations

Aug 21, 2013·Cell Communication and Signaling : CCS·Hao ZuoYung H Wong
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Apr 3, 2020·The Journal of Pathology·Jordan Da SilvaBéatrice Nawrocki-Raby
Feb 6, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Carlyne D CoolNorbert F Voelkel
Jan 17, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Audrey JoannesArnaud A Mailleux
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Jun 11, 2021·Scientific Reports·Xianglian ZhouXisong Ke
Aug 10, 2021·Frontiers in Cell and Developmental Biology·Di ZhengWeichun Guo

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