FHOD1 and FMNL1 formin proteins in intestinal gastric cancer: correlation with tumor-infiltrating T lymphocytes and molecular subtypes.

Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Naziha MansuriLaura Lehtinen

Abstract

Gastric cancer (GC) is the third most common cause of cancer death. Intestinal type GC is a molecularly diverse disease. Formins control cytoskeletal processes and have been implicated in the progression of many cancers. Their clinical significance in GC remains unclear. Here, we characterize the expression of formin proteins FHOD1 and FMNL1 in intestinal GC tissue samples and investigate their association with clinical parameters, GC molecular subtypes and intratumoral T lymphocytes. The prognostic significance of FHOD1 and FMNL1 mRNA expression was studied with Kaplan-Meier analyses in an online database. The expression of FHOD1 and FMNL1 proteins was characterized in GC cells, and in non-neoplastic and malignant tissues utilizing tumor microarrays of intestinal GC representing different molecular subtypes. FHOD1 and FMNL1 expression was correlated with clinical parameters, molecular features and T lymphocyte infiltration. Immunohistochemical expression of neither formin correlated with survival. Kaplan-Meier analysis associated high FHOD1 and FMNL1 mRNA expression with reduced overall survival (OS). Characterization of FHOD1 and FMNL1 in GC cells showed cytoplasmic expression along the actin filaments. Similar pattern was re...Continue Reading

References

Jan 1, 1986·Acta Pathologica Japonica·T MotoyamaH Watanabe
Nov 1, 2003·Biochemical and Biophysical Research Communications·Patricia M Bergamo FavaroSara Teresinha Olalla Saad
May 1, 2013·Cytoskeleton·Elisabeth C KrainerScott D Blystone
Jun 27, 2013·Journal of Leukocyte Biology·Patricia FavaroSara Teresinha Olalla Saad
Apr 5, 2014·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Maria GardbergOlli Carpén
Jun 11, 2014·Small GTPases·Sonja Kühn, Matthias Geyer
Aug 1, 2014·Nature·UNKNOWN Cancer Genome Atlas Research Network
Mar 5, 2016·CellBio·Matthew R Miller, Scott D Blystone
Dec 7, 2016·Experimental Cell Research·Minna PeippoVanina D Heuser
Oct 20, 2017·Virchows Archiv : an International Journal of Pathology·Eva-Maria BirkmanOlli Carpén
May 4, 2018·Oncotarget·Magdalena CisłoWojciech Piotr Polkowski
Jun 7, 2018·Journal of the National Cancer Institute·Willi SauerbreiDouglas G Altman
Aug 31, 2018·Breast Cancer : Basic and Clinical Research·Vanina D HeuserMaria Gardberg
Dec 22, 2019·International Journal of Molecular Sciences·Nayuta HigaKazunori Arita
May 15, 2020·Journal of Clinical Medicine·Maria Grazia RodriquenzKarol Polom
Jul 31, 2020·BMC Cancer·Vanina D HeuserMaria Gardberg
Sep 22, 2020·Virchows Archiv : an International Journal of Pathology·Naziha MansuriOlli Carpén

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.