PMID: 9007080Jan 6, 1997Paper

Fiber genes of adenoviruses with tropism for the eye and the genital tract

Virology
Niklas ArnbergGöran Wadell

Abstract

We have characterized the fibergenes of adenovirus type 19p (Ad19p), Ad19a, and Ad37 by sequencing. The fiber genes of Ad19a and Ad37 are identical and only five amino acids differ comparing Ad19a/Ad37 with Ad19p. Based on the translated sequences we calculated the isoelectrical points (Ips) and found that the fiber knobs of Ad19p, Ad19a, and Ad37 together with Ad8 display the highest Ips of all so far characterized. Two regions within the fiber knob with unusually basic characteristics have been identified. Sequence alignments revealed that the corresponding regions in other fiber knobs are highly antigenic in pepscan analysis and of importance for hemagglutination. Only two positions differ in the knobs comparing Ad19a/Ad37 with Ad19p. Hence, either of these or both amino acid residues should be expected to be responsible for the observed differences in hemagglutination between Ad19p and Ad19a/Ad37. Moreover, we have found two amino acids (Ala227 and Lys252) that are unique in their respective position in Ad19p, Ad19a, Ad37, and Ad8. Three amino acids (Lys236, Lys240, and Asn251) are unique in their respective position in Ad19a and Ad37, that manifest a tropism for the genital tract. All five amino acids colocalize within one...Continue Reading

Citations

Jan 29, 2002·Human Gene Therapy·Rima YouilDanilo Casimiro
Dec 10, 1999·Journal of Virology·N ArnbergG Wadell
Oct 24, 2000·Journal of Virology·D M Shayakhmetov, A Lieber
Aug 7, 2002·Journal of Virology·Niklas ArnbergGöran Wadell
Aug 14, 2003·Journal of Virology·Anna SegermanNiklas Arnberg
Jun 29, 2004·Journal of Virology·Wim P BurmeisterNiklas Arnberg
Oct 29, 2005·Journal of Virology·Marko MarttilaNiklas Arnberg
May 29, 2004·Journal of Clinical Pathology·A K AdhikaryN Okabe
Dec 11, 2002·Sexually Transmitted Infections·C S BradshawC K Fairley
Mar 27, 2007·Sexual Health·Sepehr N TabriziSuzanne M Garland
Jun 9, 2007·Expert Opinion on Biological Therapy·Kathryn WhiteAndrew H Baker
Jul 7, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Troy McCarthyGregory C Gray
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Aug 10, 2004·Chembiochem : a European Journal of Chemical Biology·Sunia A TraugerGary Siuzdak
Apr 16, 2009·Reviews in Medical Virology·Niklas Arnberg
Jun 24, 2010·Journal of Medical Virology·Effrossine A TsekouraAthanassios Tsakris
Feb 8, 2003·Molecular Therapy : the Journal of the American Society of Gene Therapy·Dan J Von SeggernMartin Friedlander
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May 28, 2005·The Journal of Antimicrobial Chemotherapy·Osmond J D'Cruz, Fatih M Uckun
Mar 14, 1998·Journal of Virology·P Pring-AkerblomF E Trijssenaar

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