PMID: 9174481Jun 1, 1997Paper

Fiber-supplemented enteral formula slows intestinal transit by intensifying inhibitory feedback from the distal gut

The American Journal of Clinical Nutrition
H C LinL Wang

Abstract

Because an increase in flow rate accelerates intestinal transit, a reduction in the flow rate of formula delivery is recommended frequently for treatment of diarrhea that develops during enteral feeding. Because intestinal transit is slowed by nutrient-triggered inhibitory feedback, the rate of intestinal transit during enteral feeding may depend on a balance between the accelerating effect of flow and the inhibiting effect of the nutrient load. The addition of fiber to a formula may alter this balance. By delaying absorption of nutrients, fiber may extend the length of small intestine exposed to nutrients and thereby trigger more intense inhibitory feedback. To determine whether the addition of fiber favors nutrient-triggered inhibition over flow-driven acceleration, we studied intestinal transit after perfusion of a low-residue enteral formula compared with a fiber-supplemented formula at two perfusion rates (50 or 100 mL/h for 2 h) into the duodenum of dogs each with both a duodenal and midgut fistula. With the low-residue formula, intestinal transit accelerated when the flow rate increased from 50 to 100 mL/h (P < 0.05). With the fiber-supplemented formula, however, intestinal transit was inhibited regardless of the flow ra...Continue Reading

Citations

Jan 23, 1998·JPEN. Journal of Parenteral and Enteral Nutrition·S KleinJ L Rombeau
Aug 29, 2002·The American Journal of Clinical Nutrition·Britt Burton-FreemanBarbara O Schneeman
Jul 1, 2005·Digestive Diseases and Sciences·Henry C LinUNKNOWN AMS Task Force Committee on Gastrointestinal Transit
Dec 17, 2008·Nutrition Research Reviews·G BoschM W A Verstegen
Aug 22, 2009·ANZ Journal of Surgery·Andrew Thomson
Jun 11, 2014·Critical Reviews in Food Science and Nutrition·D El KhouryG H Anderson
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·S Cattan, J Cosnes
Sep 25, 2001·Current Opinion in Clinical Nutrition and Metabolic Care·E S Debnam, G K Grimble
Sep 14, 2006·Current Gastroenterology Reports·Gregg W Van Citters, Henry C Lin
May 23, 2012·Current Obesity Reports·Michael R Lyon, Veronica Kacinik
Jul 8, 1999·The Journal of Nutrition·B O Schneeman
Mar 10, 2001·Biological Research for Nursing·U E Westfall
Sep 12, 2000·Current Gastroenterology Reports·G W Van Citters, H C Lin
Jul 2, 2005·World Journal of Gastroenterology : WJG·Gang YangYing-Li Wang
Oct 1, 2002·Comprehensive Reviews in Food Science and Food Safety·B C Tungland, D Meyer

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