Fiberoptic observation of thrombosis and thrombolysis in isolated human coronary arteries

American Heart Journal
Y UchidaT Sugimoto

Abstract

Coronary arteries isolated from cadavers autopsied within 7 hours after death were perfused with canine arterial blood, and the processes of thrombus formation at the segments stenosed with atheroma and the thrombolytic effects of urokinase were investigated by angioscopy. Ten minutes of blood perfusion caused thin mural thrombi localized at the stenotic or nonstenotic segments. During 30 minutes of blood perfusion, the thin mural thrombi of the outlet or inlet of the segment grew into a doughnut-shaped thrombus. Also, the thin mural thrombi in the stenotic segment grew into a streamer-like thrombus and drifted downstream. These thrombi grew in size with increasing perfusion time and finally obstructed the stenotic segment. Globular thrombi close to the outlet also were formed in a few preparations. Unlike the thrombi at the stenotic segment, the mural thrombi in the nonstenotic segments did not grow into massive thrombi. The thrombi were reduced in size within 10 minutes of perfusion with 320 U/ml or more of urokinase. During thrombolysis, sandstorm-like dispersion of the blood cells occurred, small fragments detached from the mother thrombus and flew downstream, or the fibrin core of the thrombus was exposed. The results indi...Continue Reading

Citations

Oct 24, 1998·Catheterization and Cardiovascular Diagnosis·K G LehmannP W Serruys
Jan 1, 1995·Heart and Vessels·Y UchidaT Morita
Jan 1, 1988·International Journal of Cardiac Imaging·M HöherH H Hilger
May 1, 1994·Journal of the American College of Cardiology·F S LarrazetH J Geschwind
Jan 30, 1992·The New England Journal of Medicine·K MizunoJ A Ambrose
Nov 10, 2001·Annual Review of Biomedical Engineering·S L Diamond
Jul 14, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Yasumi UchidaTakeshi Sakurai
Jan 1, 1993·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·K MizunoM Kikuchi
Mar 1, 1988·Clinical Cardiology·Y UchidaS Kato
Feb 1, 1993·Annals of Medicine·K Mizuno, H Nakamura

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