Fibers with polypyrrole and polythiophene phases for isolation and determination of adrenolytic drugs from human plasma by SPME-HPLC

Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Pawel OlszowyBoguslaw Buszewski

Abstract

In this study, polypyrrole (PPy) and polythiophene (PTh) SPME coatings and their ability to extract selected adrenolytic drugs with different physico-chemical properties from standard solutions and human plasma samples were evaluated. In measurements metoprolol, oxprenolol, mexiletine, propranolol, and propaphenon were investigated. The main parameters such as extraction time, desorption conditions and pH influence were examined. Inter-day precisions were in range 0.1-2.0%, 1.1-2.9%, 1.3-2.6%, 0.1-2.6% and 0.3-2.1% for metoprolol, oxprenolol, mexiletine, propranolol and propaphenon, respectively. Accuracies were less than 15%, which was evaluated by analyzing preparation samples of five replicates. The method was successfully applied to human plasma samples spiked with selected adrenolytic drugs. The method was linear in the concentration range from 1 to 10microg/ml for all of studied adrenolytic drugs using human plasma samples. The PTh-SPME coating displayed higher extraction efficiency towards the target analytes in comparison to PPy-SPME. The reproducibility of the extraction using polypyrrole and polythiophene fibers was confirmed by variation coefficients lower than 8% and 3%, respectively.

Citations

Jun 29, 2011·Analytical and Bioanalytical Chemistry·Pawel OlszowyBoguslaw Buszewski
May 21, 2013·Analytica Chimica Acta·Mohammad Ovais Aziz-Zanjani, Ali Mehdinia
May 15, 2013·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Korcan KorbaF Nil Ertaş
Sep 13, 2011·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Hiroyuki Kataoka
Apr 2, 2014·Journal of Analytical Methods in Chemistry·Mohammad Mahdi MoeinMohamed Abdel-Rehim
Aug 19, 2014·Journal of Separation Science·Malgorzata SzultkaBoguslaw Buszewski
Sep 12, 2015·Bioanalysis·Hiroyuki Kataoka
Sep 1, 2015·Critical Reviews in Analytical Chemistry·Malgorzata Szultka-MlynskaBogusław Buszewski
Jul 28, 2016·Journal of Chromatography. a·Habib BagheriSamaneh Jelvani
Jul 7, 2012·Biomedical Chromatography : BMC·Khalil FarhadiAmir Abbas Matin
Jun 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xinghua LiHongmei Shi
Jul 3, 2021·International Journal of Molecular Sciences·Seyyed Mojtaba MousaviWei-Hung Chiang

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